oru.sePublikationer
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
International renal-cell cancer study. VIII. Role of diuretics, other anti-hypertensive medications and hypertension
National Cancer Institute, Bethesda, Maryland, United States; International Epidemiology Institute, Rockville, Maryland, United States.
National Cancer Institute, Bethesda, Maryland, United States.
Division of Environmental Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States.
Danish Cancer Society, Copenhagen, Denmark.
Show others and affiliations
1995 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 63, no 2, 216-221 p.Article in journal (Refereed) Published
Abstract [en]

Risk of renal-cell cancer in relation to use of diuretics, other anti-hypertensive medications and hypertension was assessed in a multi-center, population-based, case-control study conducted in Australia, Denmark, Germany, Sweden and the United States, using a shared protocol and questionnaire. A total of 1,732 histologically confirmed cases and 2,309 controls, frequency-matched to cases by age and sex, were interviewed. The association between renal-cell cancer and the drugs was estimated by relative risks (RRs) and 95% confidence intervals (CIs). Risks were increased among users of diuretics and other anti-hypertensive medications. After adjustment for hypertension, risk for diuretics was reduced to unity, except among long-term (15+ years) users. Risk for use of non-diuretic anti-hypertensive drugs remained significantly elevated and increased further with duration of use. Overall risk was not enhanced when both classes of medications were used. Excess risk was not restricted to any specific type of diuretic or anti-hypertensive drug and no trend was observed with estimated lifetime consumption of any particular type of product. The RR for hypertension after adjustment for diuretics and other anti-hypertensive medications was 1.4 (95% CI = 1.2-1.7), although among non-users of any anti-hypertensive medications, there was little excess risk associated with a history of hypertension. Exclusion of drug use that first occurred within 5 years of cancer diagnosis or interview did not alter the associations. Our findings suggest small effects on renal-cell cancer risk associated with hypertension and use of diuretics and other anti-hypertensive medications. However, because of potential misclassifications of these highly correlated variables, it is difficult to distinguish the effect of treatment from its indication, hypertension.

Place, publisher, year, edition, pages
New York, USA: John Wiley & Sons, 1995. Vol. 63, no 2, 216-221 p.
Keyword [en]
Antihypertensive Agents/*adverse effects, Carcinoma, Renal Cell/*etiology, Case-Control Studies, Diuretics/*adverse effects/classification, Humans, Hypertension/*complications, Kidney Neoplasms/*etiology, Odds Ratio, Risk
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-48994DOI: 10.1002/ijc.2910630212ISI: A1995TB40700011PubMedID: 7591207ScopusID: 2-s2.0-0028788448ISBN: 0020-7136 (Print) 0020-7136 (Linking) OAI: oai:DiVA.org:oru-48994DiVA: diva2:1061278
Available from: 2017-01-01 Created: 2016-03-06 Last updated: 2017-01-13Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Lindblad, Per
In the same journal
International Journal of Cancer
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 2 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf