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Childhood attention-deficit/hyperactivity disorder symptoms and the development of adolescent alcohol problems: A prospective, population-based study of Swedish twins
Department of Psychological and Brain Sciences, Indiana University, Bloomington, USA.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, Sweden.
Department of Psychiatry and Neurochemistry, University of Gothenburg, Gothenburg, Sweden.
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2016 (English)In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, ISSN 1552-4841, E-ISSN 1552-485X, Vol. 171, no 7, p. 958-970Article in journal (Refereed) Published
Abstract [en]

Children with attention-deficit/hyperactivity disorder (ADHD) are at increased risk of problematic alcohol and other substance use in adolescence. This study used data from an ongoing, prospective, population-based twin study of Swedish children and adolescents to evaluate the extent to which the association between ADHD symptoms and alcohol problems reflects a unique source of genetic or environmental risk related to ADHD versus a broader predisposition to youth externalizing behavior. We used all available data from same-sex monozygotic (MZ) and dizygotic (DZ) twins on ADHD symptoms in childhood (age 9/12; N = 15,549) and alcohol problems in late adolescence (age 18; N = 2,564). Consistent with prior longitudinal studies, the phenotypic association between hyperactive/impulsive ADHD symptoms and alcohol problems was small in magnitude, whereas the association for inattentive symptoms was even weaker. Additive genetic influences explained 99.8% of the association between hyperactive/impulsive symptoms and alcohol problems. Furthermore, we found that the genetic risk specifically associated with hyperactive/impulsive symptoms was attenuated when estimated in the context of externalizing behavior liability during childhood, of which ADHD symptoms were specific expressions. In sensitivity analyses exploring hyperactivity in mid-adolescence, we found a similar pattern of genetic associations. These results are consistent with previous findings of genetically driven overlap in the etiology of ADHD and problematic alcohol use. At least some of this co-occurrence may result from a general predisposition to externalizing behaviors in youth. © 2015 Wiley Periodicals, Inc.

Place, publisher, year, edition, pages
Hoboken, USA: John Wiley & Sons, 2016. Vol. 171, no 7, p. 958-970
National Category
Medical and Health Sciences Genetics Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-54485DOI: 10.1002/ajmg.b.32412ISI: 000383600200006PubMedID: 26714985Scopus ID: 2-s2.0-84952801907OAI: oai:DiVA.org:oru-54485DiVA, id: diva2:1064248
Funder
NIH (National Institute of Health)
Note

Funding Agencies:

Swedish Initiative for Research on Microdata in the Social and Medical Sciences (SIMSAM)

Swedish Research Council for Health, Working Life and Welfare 

Swedish Research Council (Medicine and SIMSAM) 

Soderstrom-Konigska Foundation 

European Union 

Available from: 2017-01-12 Created: 2017-01-12 Last updated: 2018-07-23Bibliographically approved

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Larsson, Henrik

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