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Common psychiatric disorders share the same genetic origin: a multivariate sibling study of the Swedish population
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden .
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-6851-3297
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden .
2016 (English)In: Molecular Psychiatry, ISSN 1359-4184, E-ISSN 1476-5578, Vol. 21, no 5, 717-721 p.Article in journal (Refereed) Published
Abstract [en]

Recent studies have shown that different mental-health problems appear to be partly influenced by the same set of genes, which can be summarized by a general genetic factor. To date, such studies have relied on surveys of community-based samples, which could introduce potential biases. The goal of this study was to examine whether a general genetic factor would still emerge when based on a different ascertainment method with different biases from previous studies. We targeted all adults in Sweden (n=3 475 112) using national registers and identified those who had received one or more psychiatric diagnoses after seeking or being forced into mental health care. In order to examine the genetic versus environmental etiology of the general factor, we examined whether participants' full- or half-siblings had also received diagnoses. We focused on eight major psychiatric disorders based on the International Classification of Diseases, including schizophrenia, schizoaffective disorder, bipolar disorder, depression, anxiety, attention-deficit/hyperactivity disorder, alcohol use disorder and drug abuse. In addition, we included convictions of violent crimes. Multivariate analyses demonstrated that a general genetic factor influenced all disorders and convictions of violent crimes, accounting for between 10% (attention-deficit/hyperactivity disorder) and 36% (drug abuse) of the variance of the conditions. Thus, a general genetic factor of psychopathology emerges when based on both surveys as well as national registers, indicating that a set of pleiotropic genes influence a variety of psychiatric disorders.

Place, publisher, year, edition, pages
New York, USA: Nature Publishing Group, 2016. Vol. 21, no 5, 717-721 p.
National Category
Medical and Health Sciences Psychiatry Neurosciences Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:oru:diva-54495DOI: 10.1038/mp.2015.116ISI: 000374324000019PubMedID: 26303662Scopus ID: 2-s2.0-84940092787OAI: oai:DiVA.org:oru-54495DiVA: diva2:1064262
Funder
NIH (National Institute of Health)Swedish Research Council
Note

Funding Agencies:

Swedish Research Council for Health, Working Life, and Welfare 

Available from: 2017-01-12 Created: 2017-01-12 Last updated: 2017-10-18Bibliographically approved

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CiteExportLink to record
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