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Heritability of cortisol regulation in children
Department of Clinical and Experimental Medicine, Child and Adolescent Psychiatry, Linköping University, Linköping, Sweden.
Department of Public Health and Clinical Medicine, Family Medicine, Umeå University, Umeå, Sweden.
Department of Neuroscience and Physiology, Forensic Psychiatry, Gothenburg University, Gothenburg, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden.
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2011 (English)In: Twin Research and Human Genetics, ISSN 1832-4274, E-ISSN 1839-2628, Vol. 14, no 6, p. 553-561Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The normal development of cortisol regulation during childhood is thought to be influenced by a complex interplay between environmental and genetic factors.

METHOD: The aim of this study was to estimate genetic and environmental influences on basal cortisol levels in a sample of 151 twin pairs aged 9-16 years. Salivary cortisol was collected on two consecutive days when the children attended school--immediately after awakening, 30 min post-awakening and at bedtime.

RESULTS: Heritability was highest (60%) for cortisol levels about 30 min after awakening. For samples taken immediately at awakening heritability was less pronounced (28%) and in the evening low (8%).

CONCLUSION: The limited genetic influence on evening levels, moderate on cortisol at awakening and high on awakening response, might imply two genetic regulation patterns, one specifically for awakening response and one for the circadian rhythm proper. These findings could explain divergent results in previous studies and highlight the importance of taking the circadian rhythm into account in studies of cortisol levels in children.

Place, publisher, year, edition, pages
Australian Academic Press, 2011. Vol. 14, no 6, p. 553-561
Keywords [en]
child; twin study; heritability; basal cortisol; circadian rhythm; hypothalamic-pituitary-adrenal (HPA) axis
National Category
Genetics Obstetrics, Gynecology and Reproductive Medicine
Research subject
Genetics; Obstetrics and Gynaecology
Identifiers
URN: urn:nbn:se:oru:diva-54521DOI: 10.1375/twin.14.6.553ISI: 000298625100007PubMedID: 22506311Scopus ID: 2-s2.0-84860831383OAI: oai:DiVA.org:oru-54521DiVA, id: diva2:1064308
Funder
Swedish Research Council, 2009-4740The Swedish Brain Foundation
Note

Funding Agencies:

Swedish Medical Society/The Foundation of Söderström-Königska Sjukhemmet

Research Council in the South-East of Sweden FORSS-8324

Available from: 2017-01-12 Created: 2017-01-12 Last updated: 2018-05-07Bibliographically approved

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Larsson, Henrik

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