Study on the possible association of brain-derived neurotrophic factor polymorphism with the developmental course of symptoms of attention deficit and hyperactivityShow others and affiliations
2011 (English)In: International Journal of Neuropsychopharmacology, ISSN 1461-1457, E-ISSN 1469-5111, Vol. 14, no 10, p. 1367-1376
Article in journal (Refereed) Published
Abstract [en]
Several studies have, with conflicting results, investigated the relationship between the Val⁶⁶Met polymorphism in brain-derived neurotrophic factor (BDNF) and attention deficit hyperactivity disorder (ADHD). We assessed longitudinal, quantitative phenotypes of hyperactivity-impulsivity and inattention in order to determine whether the Val⁶⁶Met polymorphism is associated with age-specific and/or persistent symptoms of hyperactivity-impulsivity and/or inattention in a community-based cohort of 1236 Swedish individuals for which ADHD symptom data were collected when the participants were aged 8-9, 13-14 and 16-17 yr. The Met allele was associated with symptoms of ADHD at ages 8-9 and 13-14 yr. A multivariate regression analysis revealed that the observed effect of the Met allele on ADHD symptoms reflects an influence on persistent hyperactivity-impulsivity symptoms. The present findings support the hypothesis that BDNF is involved in the pathogenesis of ADHD. The results highlight the importance of distinguishing between hyperactivity-impulsivity and inattention, respectively, and demonstrate the value of using a longitudinal approach in genetic studies of ADHD symptoms.
Place, publisher, year, edition, pages
New York, USA: Cambridge University Press, 2011. Vol. 14, no 10, p. 1367-1376
Keywords [en]
ADHD, BDNF, rs6265, Val(66)Met
National Category
Medical and Health Sciences Neurosciences
Identifiers
URN: urn:nbn:se:oru:diva-54526DOI: 10.1017/S1461145711000502ISI: 000297106000007PubMedID: 21466746Scopus ID: 2-s2.0-80054977096OAI: oai:DiVA.org:oru-54526DiVA, id: diva2:1064319
Funder
The Swedish Brain FoundationSwedish Research Council
Note
Funding Agencies:
Torsten och Ragnar Soderberg's Foundation
Swedish Brain Power
Bertil Hallsten's Foundation
Institutet Center of Neurodevelopmental Disorders
2017-01-122017-01-122018-05-07Bibliographically approved