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Study on the possible association of brain-derived neurotrophic factor polymorphism with the developmental course of symptoms of attention deficit and hyperactivity
Department of Pharmacology, University of Gothenburg, Gothenburg, Sweden.
Department of Pharmacology, University of Gothenburg, Gothenburg, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Pharmacology, University of Gothenburg, Gothenburg, Sweden.
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2011 (English)In: International Journal of Neuropsychopharmacology, ISSN 1461-1457, E-ISSN 1469-5111, Vol. 14, no 10, p. 1367-1376Article in journal (Refereed) Published
Abstract [en]

Several studies have, with conflicting results, investigated the relationship between the Val⁶⁶Met polymorphism in brain-derived neurotrophic factor (BDNF) and attention deficit hyperactivity disorder (ADHD). We assessed longitudinal, quantitative phenotypes of hyperactivity-impulsivity and inattention in order to determine whether the Val⁶⁶Met polymorphism is associated with age-specific and/or persistent symptoms of hyperactivity-impulsivity and/or inattention in a community-based cohort of 1236 Swedish individuals for which ADHD symptom data were collected when the participants were aged 8-9, 13-14 and 16-17 yr. The Met allele was associated with symptoms of ADHD at ages 8-9 and 13-14 yr. A multivariate regression analysis revealed that the observed effect of the Met allele on ADHD symptoms reflects an influence on persistent hyperactivity-impulsivity symptoms. The present findings support the hypothesis that BDNF is involved in the pathogenesis of ADHD. The results highlight the importance of distinguishing between hyperactivity-impulsivity and inattention, respectively, and demonstrate the value of using a longitudinal approach in genetic studies of ADHD symptoms.

Place, publisher, year, edition, pages
New York, USA: Cambridge University Press, 2011. Vol. 14, no 10, p. 1367-1376
Keywords [en]
ADHD, BDNF, rs6265, Val(66)Met
National Category
Medical and Health Sciences Neurosciences
Identifiers
URN: urn:nbn:se:oru:diva-54526DOI: 10.1017/S1461145711000502ISI: 000297106000007PubMedID: 21466746Scopus ID: 2-s2.0-80054977096OAI: oai:DiVA.org:oru-54526DiVA, id: diva2:1064319
Funder
The Swedish Brain FoundationSwedish Research Council
Note

Funding Agencies:

Torsten och Ragnar Soderberg's Foundation

Swedish Brain Power 

Bertil Hallsten's Foundation 

Institutet Center of Neurodevelopmental Disorders 

Available from: 2017-01-12 Created: 2017-01-12 Last updated: 2018-05-07Bibliographically approved

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Larsson, Henrik

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