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The Swedish Twin Registry: establishment of a biobank and other recent developments
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Women's and Children's Health and Astrid Lindgren Children's Hospital, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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2013 (English)In: Twin Research and Human Genetics, ISSN 1832-4274, E-ISSN 1839-2628, Vol. 16, no 1, p. 317-329Article in journal (Refereed) Published
Abstract [en]

The Swedish Twin Registry (STR) today contains more than 194,000 twins and more than 75,000 pairs have zygosity determined by an intra-pair similarity algorithm, DNA, or by being of opposite sex. Of these, approximately 20,000, 25,000, and 30,000 pairs are monozygotic, same-sex dizygotic, and opposite-sex dizygotic pairs, respectively. Since its establishment in the late 1950s, the STR has been an important epidemiological resource for the study of genetic and environmental influences on a multitude of traits, behaviors, and diseases. Following large investments in the collection of biological specimens in the past 10 years we have now established a Swedish twin biobank with DNA from 45,000 twins and blood serum from 15,000 twins, which effectively has also transformed the registry into a powerful resource for molecular studies. We here describe the main projects within which the new collections of both biological samples as well as phenotypic measures have been collected. Coverage by year of birth, zygosity determination, ethnic heterogeneity, and influences of in vitro fertilization are also described.

Place, publisher, year, edition, pages
Cambridge, United Kingdom: Cambridge University Press, 2013. Vol. 16, no 1, p. 317-329
Keywords [en]
Biobank, population-based, twin, registry, Sweden
National Category
Medical and Health Sciences Genetics Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:oru:diva-54531DOI: 10.1017/thg.2012.104ISI: 000314799700048PubMedID: 23137839Scopus ID: 2-s2.0-84873917050OAI: oai:DiVA.org:oru-54531DiVA, id: diva2:1064330
Funder
Swedish Research CouncilNIH (National Institute of Health)Swedish Foundation for Strategic Research Swedish Heart Lung FoundationStockholm County Council
Note

Funding Agencies:

Ministry for Higher Education 

TwinGene 

GenomEUtwin 

Strategic Research Program in Epidemiology at Karolinska Institutet 

Swedish Asthma and Allergy Association 

Karolinska Institutet 

Swedish Council for Working Life and Social Research 

Systembolaget 

National Board of Forensic Medicine 

Swedish Prison and Probation Service 

Soderstrom-Konigska foundation 

Soderstrom-Konigska foundation  Karolinska Institutet Center of Neurodevelopmental Disorders (KIND).

Swedish Cancer Society

European Union 

Available from: 2017-01-12 Created: 2017-01-12 Last updated: 2018-05-27Bibliographically approved

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