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Stimulant and non-stimulant attention deficit/hyperactivity disorder drug use: total population study of trends and discontinuation patterns 2006-2009
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
MRC Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, Kings College London, London, UK.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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2013 (English)In: Acta Psychiatrica Scandinavica, ISSN 0001-690X, E-ISSN 1600-0447, Vol. 128, no 1, p. 70-77Article in journal (Refereed) Published
Abstract [en]

Objective: To explore the prevalence and discontinuation of dispensed medications for attention deficit/hyperactivity disorder (ADHD) drugs from 2006 to 2009.

Method: A total population cohort of all individuals aged 6-45 years, alive and registered as residents in Sweden during any calendar year from 2006 to 2009 (N = 5 149 791) included 41 700 patients dispensed with an ADHD drug (methylphenidate, atomoxetine, amphetamine, or dexamphetamine). The dispensing prevalence was calculated for each year, stratified on sex and age. A longitudinal analysis was also performed to compare the rates of treatment discontinuation across the strata.

Results: The dispensing prevalence increased from 2.93 per 1000 in 2006 to 6.98 in 2009 (PR = 2.38, 95% CI = 2.34-2.43). The prevalence ratio (PR) was 3.40 for adults, 22-45 years old; 2.41 for adolescents, 15-21 years old; and 1.90 for children aged 6-14. The increase was also greater in women than in men (PR = 2.92 vs. 2.19). Patients aged 15-21 were the most likely to discontinue treatment; after 3 years and 11 months, 27% of those patients were still under treatment.

Conclusion: From 2006 to 2009, the number of prescriptions dispensed for ADHD drugs increased substantially. The rate of treatment discontinuation in the age interval 15-21 is higher than expected considering the persistence rates of the disorder.

Place, publisher, year, edition, pages
Hoboken, USA: Wiley-Blackwell, 2013. Vol. 128, no 1, p. 70-77
Keywords [en]
Attention deficit ⁄ hyperactivity disorder, pharmacoepidemiology, psychostimulants, treatment
National Category
Medical and Health Sciences Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-54538DOI: 10.1111/acps.12004ISI: 000320133000008PubMedID: 22943458Scopus ID: 2-s2.0-84878930973OAI: oai:DiVA.org:oru-54538DiVA, id: diva2:1064340
Funder
Swedish Research Council
Note

Funding Agencies:

Karolinska Institutet Center of Neurodevelopmental Disorders (KIND)

Available from: 2017-01-12 Created: 2017-01-12 Last updated: 2017-11-29Bibliographically approved

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