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Genetic associations between the ADHD symptom dimensions and Cloninger's temperament dimensions in adult twins
MRC Social Genetic and Developmental Psychiatry Centre, PO80, Institute of Psychiatry, King's College London, London, UK.
MRC Social Genetic and Developmental Psychiatry Centre, PO80, Institute of Psychiatry, King's College London, London, UK.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Center of Neurodevelopmental Disorders, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-6851-3297
2013 (English)In: European Neuropsychopharmacology, ISSN 0924-977X, E-ISSN 1873-7862, Vol. 23, no 6, 416-425 p.Article in journal (Refereed) Published
Abstract [en]

Previous studies have identified phenotypic associations between Cloninger's temperament dimensions and the symptoms of attention deficit hyperactivity disorder (ADHD) in adults. However the underlying aetiology of these associations remains unclear. We investigate the extent to which genetic and environmental influences contribute to the relationship between temperament and ADHD, examining the ADHD symptoms of inattention (IA) and hyperactivity/impulsivity (HI) separately. Participants were 886 adult twin pairs aged 19-20 years. ADHD symptoms of IA and HI were measured using a DSM-IV based rating scale. Temperament was measured using Cloninger's Temperament and Character Inventory (TCI), across four dimensions: novelty seeking (NS), harm avoidance (HA), reward dependence (RD) and persistence (PS). The twin method was used to decompose phenotypic variance/covariance among these variables into genetic and environmental components. We found that NS was genetically associated with both ADHD symptom dimensions (IA and HI), but that HA was genetically associated with IA only. There was also some evidence of genetic association between PS, IA and HI. These findings suggest that unique profiles of temperament are genetically related to the two ADHD symptom dimensions in adults. Further work is now needed to elucidate the mechanisms that underlie both the combined and separate symptom factor domains of ADHD.

Place, publisher, year, edition, pages
Amsterdam, Netherlands: Elsevier, 2013. Vol. 23, no 6, 416-425 p.
Keyword [en]
Attention deficit hyperactivity disorder (ADHD), temperament, personality, genetic, twin study, adult
National Category
Medical and Health Sciences Psychiatry Neurosciences Neurology Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:oru:diva-54542DOI: 10.1016/j.euroneuro.2012.10.003ISI: 000320073400002PubMedID: 23122641Scopus ID: 2-s2.0-84877922297OAI: oai:DiVA.org:oru-54542DiVA: diva2:1064345
Funder
Swedish Research Council
Note

Funding Agencies:

QbTech 

Vifor 

Shire 

Janssen-Cilag 

Swedish Council for Working Life and Social Research 

Economic and Social Research Council Studentship Grant 

Available from: 2017-01-12 Created: 2017-01-12 Last updated: 2017-10-18Bibliographically approved

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Citation style
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