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Association between ASMT and autistic-like traits in children from a Swedish nationwide cohort
Department of Pharmacology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Departments of Forensic Psychiatry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg, Sweden.
Department of Pharmacology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Pharmacology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
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2014 (English)In: Psychiatric Genetics, ISSN 0955-8829, E-ISSN 1473-5873, Vol. 24, no 1, p. 21-27Article in journal (Refereed) Published
Abstract [en]

Individuals with autism spectrum disorders often show low levels of melatonin, and it has been suggested that this decrease may be because of the low activity of the acetylserotonin O-methyltransferase (ASMT), the last enzyme in the melatonin-synthesis pathway. Also, genetic variants in ASMT have been associated with autism, as well as with low ASMT activity and melatonin levels, suggesting that the low ASMT activity observed in autism may partly be because of variations within the ASMT gene. In this study, we present a symptom-based approach to investigate possible associations between ASMT and autistic-like traits in the general population. To this end, continuous measures of autistic-like traits were assessed in a nationally representative twin cohort (n=1771) from Sweden and six single nucleotide polymorphisms (SNPs), and a duplication of exons 2-8 in ASMT were genotyped. Our results show a nominally significant association, in girls, between one single nucleotide polymorphism (rs5949028) in the last intron of ASMT and social interaction impairments. No significant association, however, was observed with traits related to language impairment or restricted and repetitive behavior. In conclusion, our results support the possible involvement of the ASMT gene in autism spectrum disorders, and our finding that only one of the three traits shows association suggests that genetic research may benefit from adopting a symptom-specific approach to identify genes involved in autism psychopathology.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2014. Vol. 24, no 1, p. 21-27
Keywords [en]
acetylserotonin O-methyltransferase; autism spectrum disorders; autistic-like traits; melatonin; polymorphism
National Category
Medical Genetics Neurology
Research subject
Genetics; Neurology
Identifiers
URN: urn:nbn:se:oru:diva-54551DOI: 10.1097/YPG.0000000000000010ISI: 000329812000003PubMedID: 23995775Scopus ID: 2-s2.0-84891857237OAI: oai:DiVA.org:oru-54551DiVA, id: diva2:1064356
Funder
Swedish Research CouncilForte, Swedish Research Council for Health, Working Life and Welfare
Note

Funding Agencies:

Petrus and Augusta Hedlund Foundation

Åke Wiberg Foundation

Åhlens Foundation

Wilhelm and Martina Lundgren Foundation

Sahlgrenska Academy

Available from: 2017-01-12 Created: 2017-01-12 Last updated: 2018-06-18Bibliographically approved

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