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Maternal diabetes in pregnancy and offspring cognitive ability: sibling study with 723,775 men from 579,857 families
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Lung and Allergy Unit, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-6851-3297
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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2014 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 57, no 1, 102-109 p.Article in journal (Refereed) Published
Abstract [en]

AIMS/HYPOTHESIS: The aim of this study was to investigate the association between maternal diabetes in pregnancy and offspring cognitive ability and also to assess whether the association was due to intrauterine mechanisms or shared familial characteristics.

METHODS: We linked national registers and conducted a prospective cohort study of singleton Swedish-born men to explore associations between maternal pregnancy diabetes and educational achievement at age 16 years, the age of completing compulsory education in Sweden (n = 391,545 men from 337,174 families, graduating in 1988-1997 and n = 326,033 men from 282,079 families, graduating in 1998-2009), and intelligence quotient (IQ) at the mandatory conscription examination at 18 years of age (n = 664,871 from 543,203 families).

RESULTS: Among non-siblings, maternal diabetes in pregnancy was associated with lower offspring cognitive ability even after adjustment for maternal age at birth, parity, education, early-pregnancy BMI, offspring birth year, gestational age and birthweight. For example, in non-siblings, the IQ of men whose mothers had diabetes in their pregnancy was on average 1.36 points lower (95% CI -2.12, -0.60) than men whose mothers did not have diabetes. In comparison, we found no such association within sibships (mean difference 1.70; 95% CI -1.80, 5.21).

CONCLUSIONS/INTERPRETATION: The association between maternal diabetes in pregnancy and offspring cognitive outcomes is likely explained by shared familial characteristics and not by an intrauterine mechanism.

Place, publisher, year, edition, pages
Springer, 2014. Vol. 57, no 1, 102-109 p.
Keyword [en]
Cognition; Diabetes; IQ; Pregnancy; Sibling comparison; Swedish registers
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:oru:diva-54555DOI: 10.1007/s00125-013-3065-zISI: 000328332900013PubMedID: 24065154Scopus ID: 2-s2.0-84890933809OAI: oai:DiVA.org:oru-54555DiVA: diva2:1064361
Funder
Swedish Research Council, 80748301 K2012-99X-22008-01-3Swedish Heart Lung Foundation
Note

Funding Agencies:

UK Medical Research Council

UK Medical Research Council fellowship G0701594

Strategic Research Program in Epidemiology at Karolinska Institutet

Available from: 2017-01-12 Created: 2017-01-12 Last updated: 2017-10-18Bibliographically approved

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Citation style
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