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Enhanced neurocognitive functioning and positive temperament in twins discordant for bipolar disorder
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm; Department of Psychology, Yale University, New Haven, Conn, USA.
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm; Department of Psychology, Yale University, New Haven, Conn, USA.
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm; Department of Psychology, Yale University, New Haven, Conn, USA.
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm; Department of Psychology, Yale University, New Haven, Conn, USA.
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2014 (English)In: American Journal of Psychiatry, ISSN 0002-953X, E-ISSN 1535-7228, Vol. 171, no 11, 1191-1198 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Based on evidence linking creativity and bipolar disorder, a model has been proposed whereby factors influencing liability to bipolar disorder confer certain traits with positive effects on reproductive fitness. The authors tested this model by examining key traits known to be associated with evolutionary fitness, namely, temperament and neurocognition, in individuals carrying liability for bipolar disorder. Schizophrenia probands and their co-twins were included as psychiatric controls.

METHOD: Twin pairs discordant for bipolar disorder and schizophrenia and control pairs were identified through the Swedish Twin Registry. The authors administered a neuropsychological test battery and temperament questionnaires to samples of bipolar probands, bipolar co-twins, schizophrenia probands, schizophrenia co-twins, and controls. Multivariate mixed-model analyses of variance were conducted to compare groups on temperament and neurocognitive scores.

RESULTS: Bipolar co-twins showed elevated scores on a "positivity" temperament scale compared with controls and bipolar probands, while bipolar probands scored higher on a "negativity" scale compared with their co-twins and controls, who did not differ. Additionally, bipolar co-twins showed superior performance compared with controls on tests of verbal learning and fluency, while bipolar probands showed performance decrements across all neurocognitive domains. In contrast, schizophrenia co-twins showed attenuated impairments in positivity and overall neurocognitive functioning relative to their ill proband counterparts.

CONCLUSIONS: These findings suggest that supra-normal levels of sociability and verbal functioning may be associated with liability for bipolar disorder. These effects were specific to liability for bipolar disorder and did not apply to schizophrenia. Such benefits may provide a partial explanation for the persistence of bipolar illness in the population.

Place, publisher, year, edition, pages
American Psychiatric Publishing, 2014. Vol. 171, no 11, 1191-1198 p.
National Category
Psychiatry
Research subject
Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-54590DOI: 10.1176/appi.ajp.2014.13121683ISI: 000343968500012PubMedID: 25124743Scopus ID: 2-s2.0-84910143147OAI: oai:DiVA.org:oru-54590DiVA: diva2:1064417
Note

Funding Agency:

NIMH NIH HHS  R01MH052857

Available from: 2017-01-12 Created: 2017-01-12 Last updated: 2017-10-18Bibliographically approved

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