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Mediators of the association between parental severe mental illness and offspring neurodevelopmental problems
Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, USA.
Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, USA.
Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, USA.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-6851-3297
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2014 (English)In: Annals of Epidemiology, ISSN 1047-2797, E-ISSN 1873-2585, Vol. 24, no 9, 629-634.e1 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: Parental severe mental illness (SMI) is associated with an increased risk of offspring autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). We conducted a study to examine the extent to which risk of preterm birth, low birth weight, and small for gestational age mediated this association.

Methods: We obtained data on offspring born 1992-2001 in Sweden (n = 870,017) through the linkage of multiple population-based registers. We used logistic and Cox regression to assess the associations between parental SMI, adverse pregnancy outcomes, and offspring ASD and ADHD, as well as tested whether adverse pregnancy outcomes served as mediators.

Results: After controlling for measured covariates, maternal and paternal SMI were associated with an increased risk for preterm birth, low birth weight, and gestational age, and for offspring ASD and ADHD. These pregnancy outcomes were also associated with an increased risk of ASD and ADHD. We found that pregnancy outcomes did not mediate the association between parental SMI and offspring ASD and ADHD, as there was no substantial change in magnitude of the risk estimates after controlling for pregnancy outcomes.

Conclusions: Parental SMI and adverse pregnancy outcomes appear to be independent risk factors for offspring ASD and ADHD.

Place, publisher, year, edition, pages
New York, USA: Elsevier, 2014. Vol. 24, no 9, 629-634.e1 p.
Keyword [en]
Attention deficit hyperactivity disorder, autism spectrum disorder, infant, small for gestational age, birth weight, gestational age
National Category
Medical and Health Sciences Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:oru:diva-54591DOI: 10.1016/j.annepidem.2014.05.010ISI: 000340864600001PubMedID: 25037304Scopus ID: 2-s2.0-84906053417OAI: oai:DiVA.org:oru-54591DiVA: diva2:1064418
Funder
Swedish Research Council
Note

Funding Agencies:

National Institute of Child Health and Human Development 

National Institute of Mental Health 

Swedish council for working life and social research 

Swedish Society of Medicine

Available from: 2017-01-12 Created: 2017-01-12 Last updated: 2017-10-18Bibliographically approved

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CiteExportLink to record
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Citation style
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