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Genetic and environmental contributions to the association between attention deficit hyperactivity disorder and alcohol dependence in adulthood: A large population-based twin study
Division of Psychiatry, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Department of Specialist Medicine, Motala, Sweden; Department of Medical and Health Sciences, Division of Community Medicine Linköping University, Sweden.
Division of Psychiatry, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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2015 (English)In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, ISSN 1552-4841, E-ISSN 1552-485X, Vol. 168, no 6, 414-422 p.Article in journal (Refereed) Published
Abstract [en]

Previous research indicates that attention deficit hyperactivity disorder (ADHD) frequently co-occurs with alcohol dependence; however, the extent to which shared genetic risk factors underpin this association remains unclear. The aim of this study is to investigate the relative importance of genetic, shared, and nonshared environmental factors for the overlap between ADHD and alcohol dependence in adults. Almost 18,000 adult twins aged 20-45 years, from more than 12,000 twin pairs (5,420 complete pairs), from the population-representative Swedish Twin Registry, were included. Self-ratings were used to assess symptoms of ADHD and alcohol dependence. Twin analysis was used to determine the role of additive genetic (A), shared (C), and nonshared environmental (E) factors. As a result, we found a significant association between ADHD and alcohol dependence (odds ratio 3.58; 95% confidence interval, 2.85-4.49). Twin analysis suggested that shared genetic risk factors explained 64% of the overlap between ADHD and alcohol dependence. Nonshared environmental factors accounted for the remaining 36%, whereas the contribution of shared environmental factors was minimal. We found no support for statistically significant sex differences in the overlap between ADHD and alcohol dependence. In conclusion the overlap between ADHD and alcohol dependence in adulthood was largely explained by shared genetic risk factors. This is an important step toward understanding the underlying nature of the risk of alcohol dependence in patients with ADHD and suggests that individuals with ADHD and their family members are important targets for alcohol prevention and treatment.

Place, publisher, year, edition, pages
Hoboken, USA: Wiley-Blackwell, 2015. Vol. 168, no 6, 414-422 p.
Keyword [en]
Attention deficit hyperactivity disorder, ADHD, alcohol dependence, twin study, genetics, environment
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:oru:diva-54604DOI: 10.1002/ajmg.b.32300ISI: 000360052200003PubMedID: 25711682Scopus ID: 2-s2.0-84939567037OAI: oai:DiVA.org:oru-54604DiVA: diva2:1064433
Funder
Swedish Research Council
Available from: 2017-01-12 Created: 2017-01-12 Last updated: 2017-02-01Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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