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The association between Darier disease, bipolar disorder, and schizophrenia revisited: a population-based family study
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Swedish Prison and Probation Service R andD, Norrköping, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-6851-3297
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2015 (English)In: Bipolar Disorders, ISSN 1398-5647, E-ISSN 1399-5618, Vol. 17, no 3, p. 340-344Article in journal (Refereed) Published
Abstract [en]

Objectives: Darier disease is an autosomal dominant skin disorder caused by mutations in the ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (ATP2A2) gene and previously reported to cosegregate with bipolar disorder and schizophrenia in occasional pedigrees. It is, however, unknown whether these associations exist also in the general population, and the objective of this study was to examine this question.

Methods: We compared a national sample of individuals with Darier disease and their first-degree relatives with matched unexposed individuals from the general population and their first-degree relatives, respectively. To examine risks for bipolar disorder and schizophrenia, risk ratios and 95% confidence intervals (CIs) were estimated using conditional logistic regressions.

Results: Individuals with Darier disease had a 4.3 times higher risk of being diagnosed with bipolar disorder (95% CI: 2.6-7.3) and a 2.3 times higher risk of being diagnosed with schizophrenia (95% CI: 1.1-5.2) than matched individuals from the general population. Relatives of individuals with Darier disease had a 1.6 times higher risk of having bipolar disorder (95% CI: 1.1-2.5) than relatives of matched individuals from the general population, but no increased risk of schizophrenia (risk ratio = 0.8, 95% CI: 0.4-1.8).

Conclusions: The association between Darier disease and bipolar disorder is manifest also in the population, and our data suggest that genetic variability within the ATP2A2 gene that causes Darier disease also confers susceptibility for bipolar disorder. The Darier-causing mutations merit additional attention in molecular genetic research on bipolar disorder.

Place, publisher, year, edition, pages
Hoboken, USA: Wiley-Blackwell, 2015. Vol. 17, no 3, p. 340-344
Keywords [en]
Bipolar disorder, Darier disease, epidemiology, schizophrenia
National Category
Medical and Health Sciences Psychiatry Neurosciences
Identifiers
URN: urn:nbn:se:oru:diva-54607DOI: 10.1111/bdi.12257ISI: 000353402800011PubMedID: 25213221Scopus ID: 2-s2.0-84928159985OAI: oai:DiVA.org:oru-54607DiVA, id: diva2:1064438
Funder
Swedish Research Council
Note

Funding Agencies:

Swedish Initiative for Research on Microdata in the Social and Medical Sciences (SIMSAM) framework 

Swedish Research Council for Health, Working Life and Welfare 

Available from: 2017-01-12 Created: 2017-01-12 Last updated: 2018-01-13Bibliographically approved

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