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Acute intermittent porphyria: comorbidity and shared familial risks with schizophrenia and bipolar disorder in Sweden
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden .
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-6851-3297
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden .
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2015 (English)In: British Journal of Psychiatry, ISSN 0007-1250, E-ISSN 1472-1465, Vol. 207, no 6, p. 556-557Article in journal (Refereed) Published
Abstract [en]

Acute intermittent porphyria (AIP) has been associated with schizophrenia in some studies, but prior research is limited by the absence of comparison populations. Here, we linked Swedish registers to examine the risk of schizophrenia and bipolar disorder in 717 individuals diagnosed with AIP and their first-degree relatives, compared with matched individuals without AIP and their first-degree relatives. Individuals with AIP had a fourfold increased risk of schizophrenia or bipolar disorder. Similarly, relatives of individuals with AIP had double the risk of schizophrenia or bipolar disorder, suggesting that these associations may be as a result of common genetic influences.

Place, publisher, year, edition, pages
London, United Kingdom: Royal College of Psychiatrists , 2015. Vol. 207, no 6, p. 556-557
National Category
Medical and Health Sciences Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-54626DOI: 10.1192/bjp.bp.114.157073ISI: 000366147600016PubMedID: 26494868Scopus ID: 2-s2.0-84949782113OAI: oai:DiVA.org:oru-54626DiVA, id: diva2:1064469
Funder
Swedish Research Council
Note

Funding Agencies:

SIMSAM 

Swedish Research Council for Health, Working Life and Welfare

Available from: 2017-01-12 Created: 2017-01-12 Last updated: 2017-11-29Bibliographically approved

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CiteExportLink to record
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  • apa
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