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Comorbidity of Adult ADHD and Its Subtypes With Substance Use Disorder in a Large Population-Based Epidemiological Study
Department of Psychiatry and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Department of Medical Specialist and Department of Medicine and Health Sciences, Linköping University, Motala, Sweden.
Centre for Social and Affective Neuroscience, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-6851-3297
2016 (English)In: Journal of Attention Disorders, ISSN 1087-0547, E-ISSN 1557-1246Article in journal (Refereed) Epub ahead of print
Abstract [en]

Objective: The objective of the study is to explore the role and possible substance preference in ADHD and subtypes in substance use disorder (SUD).

Method: Using self-report data on ADHD Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV) symptoms and SUD (alcohol, illicit drugs, and nicotine) in 18,167 Swedish twins, aged 20 to 45 years, we obtained odds ratios (OR) from mixed effect logistic regression, controlling for age, sex, education, and nonindependence of twin data.

Results: Increased ADHD symptoms were significantly associated with increased odds for all SUD. ORs ranged between 1.33 for regular nicotine (95% confidence interval [CI] = [1.12, 1.59]); 2.54 for multiple drug use (95% CI = [2.00, 3.23]), and 3.58 for alcohol dependence (95% CI = [2.86, 4.49]).

Conclusion: ADHD symptoms and subtypes in the population are associated with increased risks for all SUD outcomes, with no difference between ADHD subtypes, no substance preference, and no sex differences for the comorbidity. Clinicians need to consider ADHD evaluation and treatment as part of management of SUD in adults.

Place, publisher, year, edition, pages
Thousand Oaks, USA: Sage Publications, 2016.
Keywords [en]
Adult ADHD, ADHD subtypes, alcohol, substance-related disorders, comorbidity
National Category
Medical and Health Sciences Substance Abuse Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-54655DOI: 10.1177/1087054715626511PubMedID: 26838558OAI: oai:DiVA.org:oru-54655DiVA, id: diva2:1064507
Available from: 2017-01-12 Created: 2017-01-12 Last updated: 2018-09-06Bibliographically approved

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Larsson, Henrik

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