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Commentary: How can family-based quasi-experimental designs and national registers be used to address confounding in risk factor studies of psychopathology? A reflection on Obel et al. (2016)
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.ORCID iD: 0000-0002-6851-3297
2016 (English)In: Journal of Child Psychology and Psychiatry and Allied Disciplines, ISSN 0021-9630, E-ISSN 1469-7610, Vol. 57, no 4, 538-539 p.Article in journal (Refereed) Published
Abstract [en]

Standard observational studies have reported a robust correlation between maternal smoking during pregnancy and risk of ADHD in offspring. In the accompanying article, Obel et al. used sibling-comparisons to explore the extent to which unmeasured familial confounding explains this association. This commentary highlights three important implications of the study. At a general level, Obel et al. illustrates how (1) family-based quasi-experimental designs and (2) national registers can be used to address confounding in risk factor studies of psychopathology. At a more specific level, the study suggests that maternal smoking during pregnancy is probably not a causal risk factor for ADHD.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2016. Vol. 57, no 4, 538-539 p.
Keyword [en]
Risk factors; familial confounding; maternal smoking; smoking during pregnancy; sibling-comparisons
National Category
Psychology Psychiatry
Research subject
Psychology; Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-54664DOI: 10.1111/jcpp.12519ISI: 000373113200013PubMedID: 26968316Scopus ID: 2-s2.0-84960489363OAI: oai:DiVA.org:oru-54664DiVA: diva2:1064528
Available from: 2017-01-12 Created: 2017-01-12 Last updated: 2017-10-18Bibliographically approved

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Larsson, Henrik
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