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Epidemiologiskt undersökta samband mellan Alzheimers sjukdom och faktorer i arbetsmiljön
Örebro University, School of Medical Sciences.ORCID iD: 0000-0002-4192-8273
Örebro University, Örebro University School of Business.
2015 (Swedish)Report (Refereed)
Abstract [en]

Epidemiological evidence on associations between work environment and Alzheimers disease

Lars-Gunnar Gunnarsson, assistant professor at School of Medicine, Örebro University, Sweden and

Lennart Bodin, professor emeritus, Department of Statistics, Örebro University, Sweden and senior researcher at Institute of Environmental Medicine, Karolinska Institute, Sweden.

In this systematic literature review we identified 50 original publications on associations between work and Alzheimer’s disease. GRADE guidelines were used to secure high scientific quality and reliable guidelines were applied to classify the papers. Thirty-one papers fulfilled high quality standards while 19 were methodologically deficient and thus were excluded from our meta-analyses.

Twenty-seven studies concerned exposure to electromagnetic fields and two published meta-analyses indicated a weighted relative risk (RR) reaching 2.0. Our meta-analysis was only based on twelve high quality publications and the weighted relative risk included statistically over chemicals was evaluated in seven studies and the weighted RR was 1.55 (95% confidence interval 1.19-2.02). Only some few publications concerned pesticides and other chemicals and the weighted RR indicated increased risk.

Higher education and work complexity were evaluated in eleven publications and our meta-analysis show a reduced the risk for Alzheimer’s disease. The weighted RR was 0.47 (95% confidence interval 0.35-0.63). Both factors were independently and additively protective.

There are indications of an association between ALS and exposure to heavy muscle work especially in combination with muscle trauma, i.e. professional football players are reported to have an elevated risk. More studies are needed with more precise measures on these exposures.

Place, publisher, year, edition, pages
Göteborg: Göteborgs universitet , 2015. , 58 p.
Series
Arbete och Hälsa, ISSN 0346-7821 ; 49(3)
National Category
Other Medical Sciences not elsewhere specified Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Epidemiology
Identifiers
URN: urn:nbn:se:oru:diva-54878ISBN: 978-91-85971-55-8 (print)OAI: oai:DiVA.org:oru-54878DiVA: diva2:1067139
Available from: 2017-01-20 Created: 2017-01-20 Last updated: 2017-10-18Bibliographically approved

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Gunnarsson, Lars-GunnarBodin, Lennart
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Other Medical Sciences not elsewhere specifiedPublic Health, Global Health, Social Medicine and Epidemiology

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  • apa
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