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Circulating levels of persistent organic pollutants are related to retrospective assessment of life-time weight change
Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.
Department of Preventative Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA; Department of Nutrition, School of Medicine, University of Oslo, Oslo, Norway, USA.
Örebro University, School of Science and Technology. (MTM Research Center)ORCID iD: 0000-0001-5752-4196
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2013 (English)In: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 90, no 3, 998-1004 p.Article in journal (Refereed) Published
Abstract [en]

Background: Persistent organic pollutants (POPs) have been suggested to be linked to obesity. We have previously shown that less-chlorinated PCBs were positively related to fat mass, while highly-chlorinated PCBs were inversely related to obesity.

Objective: The aim of the present evaluation is to investigate the relationship between retrospective assessed life-time change in body weight (20-70 years) with circulating POP levels measured at age 70 years.

Methods: 1016 subjects aged 70 years were investigated in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUSs) study. 16 PCBs and 3 OC pesticides were analyzed using HRGC/HRMS. Current body weight was measured and participants self-reported their weight at age 20.

Results: The average estimated weight change over 50 years was 14.4 kg. Both the sum of OC pesticide concentrations (4.3 kg more weight gain in quintile 5 vs. quintile 1, p < 0.0001) and the sum of the less-chlorinated PCBs were positively related to the estimated weight change (3.7 kg more weight gain in quintile 2 vs. quintile 1, non-linear relationship p = 0.0015). In contrast, the sum of concentrations of highly-chlorinated PCBs were inversely related to estimated weight change (8.4 kg less weight gain in quintile 5 vs. quintile 1, p < 0.0001).

Conclusion: High levels of OC pesticides and the less-chlorinated PCBs at age 70 were associated with a pronounced estimated weight change over the previous 50 years. However, the opposite was seen for highly-chlorinated PCBs. Differences in mode of action, toxicokinetics, non-linear relationships and reverse causation might explain these discrepancies.

Place, publisher, year, edition, pages
Pergamon-Elsevier Science Ltd , 2013. Vol. 90, no 3, 998-1004 p.
Keyword [en]
Obesity, Persistent organic pollutants, Fat mass, Elderly, Life time weight change
National Category
Environmental Sciences Environmental Health and Occupational Health Nutrition and Dietetics
Research subject
Enviromental Science
Identifiers
URN: urn:nbn:se:oru:diva-54879DOI: 10.1016/j.chemosphere.2012.07.051ISI: 000312978700016PubMedID: 22921642Scopus ID: 2-s2.0-84869885421OAI: oai:DiVA.org:oru-54879DiVA: diva2:1067272
Funder
Swedish Research CouncilSwedish Research Council for Environment, Agricultural Sciences and Spatial Planning
Available from: 2017-01-20 Created: 2017-01-20 Last updated: 2017-10-18Bibliographically approved

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