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Regulation of zebrafish gonadal sex differentiation
Örebro University, School of Science and Technology.ORCID iD: 0000-0003-3302-7106
Örebro University, School of Science and Technology.ORCID iD: 0000-0001-7336-6335
2016 (English)In: AIMS Molecular Science, ISSN 2372-028X, Vol. 3, no 4, 567-584 p.Article, review/survey (Refereed) Published
Abstract [en]

While the master regulator gene Sry on the mammalian Y chromosome controls the switch for initiating male sex differentiation, many other species rely on environmental factors for gonadal sex differentiation. Yet other species, like zebrafish, appears to rely on a multitude of genetic cues for gonadal sex differentiation. Zebrafish gonadal differentiation initiates with the onset of a juvenile ovary stage and depending on the influence of unknown genetic factors either maintains oocyte development or initiate apoptotic processes to override the female differentiation pathway. In this review, we explore the role of different factors and genes that have been reported to influence zebrafish gonadal sex differentiation. We also give a brief insight of primordial germ cell (PGC) involvement in shaping male and female signaling pathway in gonadal development.

Place, publisher, year, edition, pages
American Institute of Mathematical Sciences, 2016. Vol. 3, no 4, 567-584 p.
Keyword [en]
NF kappa B, prostaglandin, retinoic acid, gonads, primordial germ cell, gene regulation, sex chromosome
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:oru:diva-55087DOI: 10.3934/molsci.2016.4.567ISI: 000390892700005OAI: oai:DiVA.org:oru-55087DiVA: diva2:1070027
Funder
Swedish Research CouncilKnowledge Foundation
Note

Funding Agency:

Örebro University

Available from: 2017-01-31 Created: 2017-01-31 Last updated: 2017-10-18Bibliographically approved

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