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Prognostic significance of phospho-histone H3 in prostate carcinoma
Inst Pathol, Univ Hosp Bonn, Bonn, Germany.; Dept Prostate Canc Res, Univ Hosp Bonn, Bonn, Germany..
Örebro University Hospital. Dept Lab Med, Univ Hosp Örebro, Örebro, Sweden; Dept Urol, Univ Hosp Örebro, Örebro, Sweden; Inst Hlth & Med Sci, Univ Örebro, Örebro, Sweden.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital. Dept Urol, Örebro, Örebro University Hospital, Örebro, Sweden.
Inst Pathol, Univ Hosp Bonn, Bonn, Germany; Dept Prostate Canc Res, Univ Hosp Bonn, Bonn, Germany.
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2014 (English)In: World journal of urology, ISSN 0724-4983, E-ISSN 1433-8726, Vol. 32, no 3, p. 703-707Article in journal (Refereed) Published
Abstract [en]

Prostate cancer is the second most common cancer in men and the sixth most common cause of death from cancer in men worldwide. Currently, a sufficient pathological distinction between patients requiring further treatment and those for which active surveillance remains an option is still lacking, which leads to the problem of overtreatment. Cell proliferation is routinely assessed by detecting Ki-67 antigen. While Ki-67 is expressed throughout the interphase of proliferating cells, phosphorylation of the chromatin constituent histone H3 occurs only during the late G2 phase and mitosis thus providing a more strict assessment of the mitotic activity. We undertook this study to test whether expression of the recently introduced proliferation marker phospho-histone H3 (pHH3) in prostate carcinoma tissue sections exhibits prognostic significance in comparison with Ki-67. Protein expression of pHH3 and Ki-67 was assessed on TMA consisting of paraffin-embedded tissue from men that had undergone radical prostatectomy. The analysis included triplicate tissue cores of a total of 339 tumor foci. Immunohistochemical staining of pHH3 and Ki-67 was performed and analyzed using Definiens imaging software. Prostate cancer tissue exhibited a significantly higher frequency of pHH3-positive cells compared to benign prostate tissue. pHH3 expression was significantly correlated with Ki-67 expression. Furthermore, statistical analysis revealed positive correlation between pHH3 expression and PSA levels at diagnosis and in addition negatively correlated with overall survival. In contrast to Ki-67 staining, pHH3 expression did not correlate with Gleason grade. Our data point to a conceivable role of pHH3 as prognostic biomarker in prostate carcinoma.

Place, publisher, year, edition, pages
Springer-Verlag New York, 2014. Vol. 32, no 3, p. 703-707
Keyword [en]
Prostate cancer, Phospho-histone H3, Mitosis, Prognostic marker
National Category
Urology and Nephrology
Identifiers
URN: urn:nbn:se:oru:diva-55182DOI: 10.1007/s00345-013-1135-yISI: 000336405800018PubMedID: 23887713Scopus ID: 2-s2.0-84901504127OAI: oai:DiVA.org:oru-55182DiVA, id: diva2:1070574
Note

Funding Agency:

German Research Foundation [Deutsche Forschungsgemeinschaft (DFG)] PE1179/2-1

Wilhelm Sander Foundation 2011.077.1 

Rudolf-Becker-Foundation 

Available from: 2017-02-01 Created: 2017-02-01 Last updated: 2018-06-18Bibliographically approved

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Carlsson, JessicaKebschull, MoritzAndren, Ove

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Svensson, Maria A.Carlsson, JessicaKebschull, MoritzAndren, Ove
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Örebro University HospitalSchool of Health and Medical Sciences, Örebro University, Sweden
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