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Aromatase inhibitors affect vaginal proliferation and steroid hormone receptors
Uppsala Univ, Dept Womens & Childrens Hlth, SE-75185 Uppsala, Sweden..
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital. Dept Obstet & Gynecol.
Uppsala Univ, Dept Womens & Childrens Hlth, SE-75185 Uppsala, Sweden..
Örebro University, School of Medicine, Örebro University, Sweden. Örebro University Hospital. Dept Obstet & Gynecol.
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2014 (English)In: Menopause: The Journal of the North American Menopause, ISSN 1072-3714, E-ISSN 1530-0374, Vol. 21, no 4, 383-390 p.Article in journal (Refereed) Published
Abstract [en]

Objective: Women with breast cancer who are treated with aromatase inhibitors often experience vaginal atrophy symptoms and sexual dysfunction. This work aims to study proliferation and the presence and distribution of steroid hormone receptors in vaginal biopsies in relation to vaginal atrophy and vaginal pH in women with breast cancer who are on adjuvant endocrine treatment and in healthy postmenopausal women.

Methods: This is a cross-sectional study that compares postmenopausal aromatase inhibitor-treated women with breast cancer (n = 15) with tamoxifen-treated women with breast cancer (n = 16) and age-matched postmenopausal women without treatment (n = 19) or with vaginal estrogen therapy (n = 16). Immunohistochemistry was used to study proliferation and steroid hormone receptor staining intensity. Data was correlated with estrogen and androgen levels, vaginal atrophy scores, and vaginal pH.

Results: Aromatase inhibitor-treated women had a lower grade of proliferation, weaker progesterone receptor staining, and stronger androgen receptor staining, which correlated with plasma estrone levels, vaginal atrophy scores, and vaginal pH.

Conclusions: Women with aromatase inhibitor-treated breast cancer exhibit reduced proliferation and altered steroid hormone receptor staining intensity in the vagina, which are related to clinical signs of vaginal atrophy. Although these effects are most probably attributable to estrogen suppression, a possible local inhibition of aromatase cannot be ruled out.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2014. Vol. 21, no 4, 383-390 p.
Keyword [en]
Aromatase inhibitors, Steroid hormone receptors, Vaginal atrophy
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:oru:diva-55187DOI: 10.1097/GME.0b013e31829e41dfISI: 000336214200012PubMedID: 24080848Scopus ID: 2-s2.0-84897538695OAI: oai:DiVA.org:oru-55187DiVA: diva2:1070613
Funder
Swedish Cancer Society, CAN 2012/603
Note

Funding Agnecy:

Uppsala-Örebro Regional Research Council 

Lions Club International  

Percy Falk Foundation 

Available from: 2017-02-01 Created: 2017-02-01 Last updated: 2017-10-18Bibliographically approved

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Baumgart, JulianeNilsson, Kerstin
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School of Health and Medical Sciences, Örebro University, SwedenÖrebro University HospitalSchool of Medicine, Örebro University, Sweden
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Menopause: The Journal of the North American Menopause
Obstetrics, Gynecology and Reproductive Medicine

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