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Regulation of myogenesis and skeletal muscle regeneration: effects of oxygen levels on satellite cell activity
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. (MIPA)ORCID iD: 0000-0002-5322-4150
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
2016 (English)In: The FASEB Journal, ISSN 0892-6638, E-ISSN 1530-6860, Vol. 30, no 12, 3929-3941 p.Article, review/survey (Refereed) Published
Abstract [en]

Reduced oxygen (O2) levels (hypoxia) are present during embryogenesis and exposure to altitude and in pathologic conditions. During embryogenesis, myogenic progenitor cells reside in a hypoxic microenvironment, which may regulate their activity. Satellite cells are myogenic progenitor cells localized in a local environment, suggesting that the O2 level could affect their activity during muscle regeneration. In this review, we present the idea that O2 levels regulate myogenesis and muscle regeneration, we elucidate the molecular mechanisms underlying myogenesis and muscle regeneration in hypoxia and depict therapeutic strategies using changes in O2 levels to promote muscle regeneration. Severe hypoxia (≤1% O2) appears detrimental for myogenic differentiation in vitro, whereas a 3-6% O2 level could promote myogenesis. Hypoxia impairs the regenerative capacity of injured muscles. Although it remains to be explored, hypoxia may contribute to the muscle damage observed in patients with pathologies associated with hypoxia (chronic obstructive pulmonary disease, and peripheral arterial disease). Hypoxia affects satellite cell activity and myogenesis through mechanisms dependent and independent of hypoxia-inducible factor-1α. Finally, hyperbaric oxygen therapy and transplantation of hypoxia-conditioned myoblasts are beneficial procedures to enhance muscle regeneration in animals. These therapies may be clinically relevant to treatment of patients with severe muscle damage.-Chaillou, T. Lanner, J. T. Regulation of myogenesis and skeletal muscle regeneration: effects of oxygen levels on satellite cell activity.

Place, publisher, year, edition, pages
Bethesda, USA: Federation of American Societies for Experimental Biology , 2016. Vol. 30, no 12, 3929-3941 p.
Keyword [en]
Hypoxia, muscle damage, hyperbaric oxygen therapy, ischemia, cell transplantation
National Category
Medical and Health Sciences Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:oru:diva-55279DOI: 10.1096/fj.201600757RISI: 000388201500003PubMedID: 27601440Scopus ID: 2-s2.0-85002156949OAI: oai:DiVA.org:oru-55279DiVA: diva2:1071039
Funder
Wenner-Gren Foundations
Available from: 2017-02-02 Created: 2017-02-02 Last updated: 2017-10-18Bibliographically approved

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CiteExportLink to record
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