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Pre- and postnatal administration of Lactobacillus reuteri decreases TLR2 responses in infants
Linköping Univ, Div Clin Immunol, Unit Autoimmun & Immune Regulat, Dept Clin & Expt Med, SE-58185 Linköping, Sweden..
Linköping Univ, Div Pediat, Dept Clin & Expt Med, Linköping, Sweden.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
Linköping Univ, Div Clin Immunol, Unit Autoimmun & Immune Regulat, Dept Clin & Expt Med, SE-58185 Linköping, Sweden.
2014 (English)In: Clinical and Translational Allergy, ISSN 2045-7022, E-ISSN 2045-7022, Vol. 4, 21Article in journal (Refereed) Published
Abstract [en]

Background: Mice models indicate that intact Toll like receptor (TLR) signaling may be essential for the allergy protective effects of diverse bacterial exposure observed in clinical trials and epidemiological studies. Probiotic supplementation with Lactobacillus reuteri from pregnancy week 36 and to the infant through the first year of life decreased the prevalence of IgE-associated eczema at two years (ClinicalTrials. gov NCT01285830). The effect of this supplementation on innate immune responses to bacterial products and the expression of associated TLRs were explored.

Methods: Blood mononuclear cells were collected at birth, 6, 12 and 24 months from 61 infants and cultured with TLR2, 4 and 9 ligands. Cytokine and chemokine secretion was determined as well as TLR2, 4 and 9 mRNA expression. Results: Probiotic supplementation was associated with decreased LTA (lipoteichoic acid) induced CCL4, CXCL8, IL-1 beta and IL-6 responses at 12 months and decreased CCL4 and IL-1 beta secretion at 24 months. TLR2 mRNA expression was not affected by probiotic treatment.

Conclusions: Decreased responses to TLR2, the main receptor for LTA from Gram positive bacteria, in probiotic treated children seem to be dependent on factors downstream of TLR mRNA expression.

Place, publisher, year, edition, pages
BioMed Central, 2014. Vol. 4, 21
Keyword [en]
Lactobacillus reuteri, Allergy, TLR, Cytokine, Chemokine, Infancy, Probiotics, Sensitization, Eczema
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:oru:diva-55397DOI: 10.1186/2045-7022-4-21ISI: 000209839200020PubMedID: 25002964Scopus ID: 2-s2.0-84978024396OAI: oai:DiVA.org:oru-55397DiVA: diva2:1072059
Funder
Swedish Research Council, K2011-56X-21854-01-06Ekhaga FoundationSwedish Heart Lung FoundationMedical Research Council of Southeast Sweden (FORSS), F2000-106Swedish Asthma and Allergy AssociationCancer and Allergy Foundation
Note

Funding Agency:

Olle Engkvist Foundation 

University Hospital of Linköping, Sweden 

Available from: 2017-02-07 Created: 2017-02-07 Last updated: 2017-02-07Bibliographically approved

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Björksten, Bengt
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School of Health and Medical Sciences, Örebro University, Sweden
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