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Graft patency is associated with higher health-related quality of life after coronary artery bypass surgery
Örebro University Hospital. Örebro University, School of Medical Sciences. Department of Cardiothoracic and Vascular Surgery, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0003-4249-8401
Örebro University, Örebro University School of Business. Intervention and Implementation Research, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. University Health Care Research Center, Region Örebro County, Örebro, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Radiology, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0003-3253-8967
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2016 (English)In: Interactive Cardiovascular and Thoracic Surgery, ISSN 1569-9293, E-ISSN 1569-9285, Vol. 24, no 3, p. 388-394Article in journal (Refereed) Published
Abstract [en]

Objectives: The objective of this study was to investigate whether graft patency was associated with higher health-related quality of life in coronary artery bypass grafting patients and to compare this study with the general Swedish population.

Methods: Patients were included from 3 randomized trials and 1 prospective cohort trial. The generic health-related quality of life instrument, EQ-5D (VAS and index) was used. Graft patency was assessed with computed tomography angiography. Patients were divided into 2 groups according to the number of occluded distal anastomosis: Group I with no to 1 occlusion (n = 209) and Group II with 2 to 4 occlusions (n = 24).

Results: Two hundred and thirty-three patients underwent computed tomography angiography at a mean of 7.5 (1-18) years post-operatively. The mean difference in EQ-VAS and EQ-5D index between Groups II and I after model adjustment was -19.8 (95% CI -25.3 to -14.3; P < 0.001) and -0.13 (95% CI -0.19 to -0.08; P < 0.001), respectively. The EQ-5D index for the study population was similar compared with the Swedish population, 0.851 and 0.832, respectively, with an effect-size of 0.112 (trivial). The EQ-5D index of the study population was higher compared with the ischemic heart disease group in the Swedish population, 0.851 vs 0.60, with an effect-size of 0.999 (large).

Conclusion: Graft patency was associated with higher health-related quality of life in coronary artery bypass patients. This patient group reported similar function and wellbeing compared to the general Swedish population and better health status than those in the same disease group in the general population.

Clinical registration number: Clinicaltrials.gov: NCT02547194 and the Research and Development registry in Sweden: 167861.

Place, publisher, year, edition, pages
Oxford, USA: Oxford University Press, 2016. Vol. 24, no 3, p. 388-394
Keywords [en]
Coronary artery bypass grafting, EQ-5D, health-related quality of life, left internal thoracic artery, no-touch saphenous
National Category
Cardiac and Cardiovascular Systems Surgery
Research subject
Cardiology; Surgery
Identifiers
URN: urn:nbn:se:oru:diva-54392DOI: 10.1093/icvts/ivw372ISI: 000402105800013PubMedID: 28040753Scopus ID: 2-s2.0-85019919827OAI: oai:DiVA.org:oru-54392DiVA, id: diva2:1072581
Note

Funding Agency:

Örebro County Council through regional research board and Nyckelfonden  OLL-505531  OLL-525111

Available from: 2017-02-08 Created: 2017-01-10 Last updated: 2018-07-23Bibliographically approved

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Samano, NinosBodin, LennartKarlsson, JanGeijer, Håkan

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