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Reduced risk of breast, endometrial and ovarian cancer in women with celiac disease
Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0003-1024-5602
Division of Epidemiology and Public Health, University of Nottingham, Nottingham City Hospital, Nottingham, United Kingdom.ORCID iD: 0000-0002-1135-9356
Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden; Department of Women's and Children's Health, Karolinska University Hospital and Institutet, Stockholm, Sweden.
2012 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 131, no 3, E244-E250 p.Article in journal (Refereed) Published
Abstract [en]

Women with celiac disease (CD) may be at decreased risk of female hormone-related cancers given the observed reduction in breast cancer seen in some cohorts. Using biopsy data from all 28 pathology departments in Sweden, we identified 17,852 women with CD who were diagnosed between 1969 and 2007. We used Cox regression model to estimate their risk of breast, endometrial and ovarian cancer and then compared them with 88,400 age- and sex-matched controls. The results indicate that individuals with CD were at a lower risk for all three outcomes: breast cancer (hazard ratio, HR = 0.85; 95% CI = 0.721.01), endometrial cancer (HR = 0.60; 95% CI =0.410.86) and ovarian cancer (HR = 0.89; 95% CI =0.591.34). This inverse relationship was strengthened when we excluded the first year of follow-up beyond CD diagnosis (breast: HR = 0.82; 95% CI =0.680.99; endometrial: HR = 0.58; 0.390.87; ovarian cancer: HR = 0.72; 0.451.15). In conclusion, CD seems to be inversely related not only to breast cancer but also to endometrial and ovarian cancer. Potential explanations include shared risk factors and early menopause.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2012. Vol. 131, no 3, E244-E250 p.
Keyword [en]
autoimmunity, breast cancer, cancer, celiac, cohort study, gluten intolerance, inflammation, malignancy, population-based
National Category
Cancer and Oncology
Research subject
Oncology
Identifiers
URN: urn:nbn:se:oru:diva-55730DOI: 10.1002/ijc.26454ISI: 000304440100009PubMedID: 21953605Scopus ID: 2-s2.0-84857355467OAI: oai:DiVA.org:oru-55730DiVA: diva2:1074474
Funder
Swedish Research CouncilSwedish Society of Medicine
Note

Funding Agencies:

Örebro University Hospital Research Foundation

Örebro University

Sven Jerring Foundation

Örebro Society of Medicine

Karolinska Institutet

Clas Groschinsky Foundation

Juhlin Foundation

Majblomman Foundation

Uppsala-rebro Regional Research Council

Swedish Celiac Society

UK National Institute for Health Research

Stockholm County Council

Available from: 2017-02-15 Created: 2017-02-15 Last updated: 2017-10-18Bibliographically approved

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