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Long term results of PDR brachytherapy for lip cancer
Örebro University Hospital. Department of Oncology.
Örebro University, School of Health and Medical Sciences. 2Department of Medical Physics, Örebro University Hospital and Örebro University, Sweden.
Örebro University, School of Health and Medical Sciences. Örebro University Hospital. Department of Medical Physics.
Örebro University, School of Health and Medical Sciences. Örebro University Hospital. Department of Medical Physics.
2011 (English)In: Journal of Contemporary Brachytherapy, ISSN 1689-832X, E-ISSN 2081-2841, Vol. 3, no 2, 65-69 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: To evaluate the long time outcome with regard to local tumour control and side effects of a pulsed dose rate (PDR) monobrachytherapy of primary or recurrent cancer of the lip.

Material and methods: Between 1995 and 2007 we treated 43 patients with primary or recurrent clinical T1-T3N0 lip cancers. There were 22 T1 patients (51%), 16 T2 (37%) and 5 T3 cases (12%). A median dose of 60 (55-66) Gy was given, depending on the tumour volume. The PDR treatment was delivered with 0.83 Gy/pulse every second hour for 5.5-6.5 days. The patients were followed for a median of 55 (1-158) months.

Results: The 2-, 5- and 10-year rates of actuarial local control were 97.6%, 94.5% and 94.5%, overall survival 88.0%, 58.9% and 39.1%, disease free survival 92.7%, 86.4% and 86.4% respectively. The regional control rate was 93%. One patient (2%) developed distant metastases. A dosimetrical analysis showed a mean treated volume of 14.9 (3.0-56.2) cm(3). Long-term side effects were mild and the cosmetic outcome excellent, except for 1 case (2%) of soft tissue necrosis and 1 case (2%) of osteoradionecrosis.

Conclusions: Local outcome is excellent and similar to other published studies of continuous low dose rate (cLDR) brachytherapy.

Place, publisher, year, edition, pages
Termedia Publishing House , 2011. Vol. 3, no 2, 65-69 p.
Keyword [en]
brachytherapy, PDR, lip cancer
National Category
Cancer and Oncology Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:oru:diva-55734DOI: 10.5114/jcb.2011.23199ISI: 000208986600001PubMedID: 27895671Scopus ID: 2-s2.0-79960159475OAI: oai:DiVA.org:oru-55734DiVA: diva2:1074485
Note

Funding Agencies:

Weiderman donation

Svenssons memorial foundation and research committee of Orebro county council

Available from: 2017-02-15 Created: 2017-02-15 Last updated: 2017-10-18Bibliographically approved

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Johansson, BengtKarlsson, LeifHardell, LennartPersliden, Jan
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