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Increased risk of uveitis in coeliac disease: a nationwide cohort study
Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden.
St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden.
Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0003-1024-5602
2012 (English)In: British Journal of Ophthalmology, ISSN 0007-1161, E-ISSN 1468-2079, Vol. 96, no 6, 857-861 p.Article in journal (Refereed) Published
Abstract [en]

Background: Case reports suggest a potential association between coeliac disease (CD) and uveitis, but larger well-controlled studies are lacking. The aim of this study was therefore to examine the risk of uveitis in patients with biopsy-verified CD.

Methods: Small intestinal biopsy reports performed between July 1969 and February 2008 were collected from all (n-28) pathology departments in Sweden. From these reports, 29 044 patients with CD (equals villous atrophy, Marsh 3) were identified. Uveitis was defined according to relevant International Classification of Disease codes in the Swedish National Patient Register. Cox regression was used to estimate HR for uveitis in individuals with CD compared with those in reference individuals matched for age, sex, county and calendar year.

Results: During follow-up, 148 patients with CD developed uveitis (expected count 112), corresponding to a HR of 1.32 (95% CI 1.10 to 1.58). The absolute risk of uveitis was 50/100 000 person-years in CD. The risk estimate did not change more than marginally when adjusted for type 1 diabetes, rheumatoid arthritis and autoimmune thyroid disease (HR 1.30; 95% CI 1.08 to 1.56). The risk of uveitis remained significantly increased even 5 years after CD diagnosis (HR 1.31; 95% CI 1.04 to 1.64).

Conclusion: A moderately increased risk of uveitis was found in patients with biopsy- verified CD. CD might be considered in patients with uveitis of unknown aetiology.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2012. Vol. 96, no 6, 857-861 p.
National Category
Ophthalmology
Identifiers
URN: urn:nbn:se:oru:diva-55810DOI: 10.1136/bjophthalmol-2011-301051ISI: 000304346300019PubMedID: 22408231Scopus ID: 2-s2.0-84861330912OAI: oai:DiVA.org:oru-55810DiVA: diva2:1074789
Funder
Swedish Society of MedicineSwedish Research Council, 522-2A09-195
Note

Funding Agencies:

Medical training and clinical research (ALF)

Karolinska Institutet, Stockholm

Sven Jerring Foundation and Ogonfonden

Örebro Society of Medicine

Karolinska Institutet, Örebro University Hospital

Clas Groschinsky Foundation

Juhlin Foundation

Majblomman Foundation, Uppsala-Orebro Regional Research Council 

Swedish Coeliac Society

Available from: 2017-02-16 Created: 2017-02-16 Last updated: 2017-10-18Bibliographically approved

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