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Increased risk of epilepsy in biopsy-verified celiac disease: A population-based cohort study
Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0003-1024-5602
Department of Clinical and Experimental Medicine, Federico II University of Naples, Naples, Italy.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
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2012 (English)In: Neurology, ISSN 0028-3878, E-ISSN 1526-632X, Vol. 78, no 18, p. 1401-1407Article in journal (Refereed) Published
Abstract [en]

Objectives: Celiac disease (CD) is associated with several neurologic disorders but it is unclear whether CD is associated with epilepsy. We therefore investigated whether biopsy-verified CD is associated with epilepsy.

Methods: Cohort study. Using biopsy report data from all Swedish pathology departments (n = 28), we identified individuals with CD who were diagnosed from 1969 to 2008 (Marsh 3: villous atrophy). Through Cox regression, we calculated hazard ratios (HRs) for epilepsy (defined as a diagnosis of epilepsy in the Swedish National Patient Register) in 28,885 individuals with CD and 143,166 controls matched for age, sex, calendar period, and county.

Results: Individuals with CD were at an increased risk of future epilepsy (HR = 1.42; 95% confidence interval [CI] = 1.24-1.62) (272 individuals with CD had a diagnosis of epilepsy vs an expected 192). The absolute risk of future epilepsy in patients with CD was 92/100,000 person-years (excess risk = 27/100,000 person-years). This risk increase was seen in all ages, including children with CD. The HR for having at least 2 interactions with health care due to epilepsy was 1.41 (95% CI = 1.19-1.66). When we restricted epilepsy to those with both a diagnosis of epilepsy and an independent record of antiepileptic drug prescriptions, CD was associated with a 1.43-fold increased risk of epilepsy (95% CI = 1.10-1.86).

Conclusion: Individuals with CD seem to be at a moderately increased risk of epilepsy. Neurology (R) 2012;78:1401-1407

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2012. Vol. 78, no 18, p. 1401-1407
National Category
Neurology
Research subject
Neurology
Identifiers
URN: urn:nbn:se:oru:diva-55811DOI: 10.1212/WNL.0b013e3182544728ISI: 000303498000010PubMedID: 22517096Scopus ID: 2-s2.0-84860703634OAI: oai:DiVA.org:oru-55811DiVA, id: diva2:1074824
Funder
Swedish Society of MedicineSwedish Research Council, 522-2A09-195
Note

Funding Agencies:

Sven Jerring Foundation

Örebro Society of Medicine

Karolinska Institutet, Örebro University Hospital

Clas Groschinsky Foundation

Juhlin Foundation

Majblomman Foundation, Uppsala-Örebro Regional Research Council

Swedish Celiac Society

Stockholm County Council

Eisai

GlaxoSmithKline

Johnson & Johnson/Janssen-Cilag Novartis

Sanofi-Aventis

Pfizer

UCB

Available from: 2017-02-16 Created: 2017-02-16 Last updated: 2017-11-29Bibliographically approved

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CiteExportLink to record
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