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Primary Hyperparathyroidism and Celiac Disease: A Population-Based Cohort Study
Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0003-1024-5602
Department of Medical Sciences, University Hospital, Uppsala University, Uppsala, Sweden.ORCID iD: 0000-0001-6091-9914
Celiac Disease Center, Columbia University College of Physicians and Surgeons, New York NY, United States.
Celiac Disease Center, Columbia University College of Physicians and Surgeons, New York NY, United States.
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2012 (English)In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 97, no 3, p. 897-904Article in journal (Refereed) Published
Abstract [en]

Context: Celiac disease (CD) has been linked to several endocrine disorders, including type 1 diabetes and thyroid disorders, but little is known regarding its association to primary hyperparathyroidism (PHPT).

Objective: The aim of the study was to examine the risk of PHPT in patients with CD.

Design and Setting: We conducted a two-group exposure-matched nonconcurrent cohort study in Sweden. A Cox regression model estimated hazard ratios (HR) for PHPT.

Participants: We identified 17,121 adult patients with CD who were diagnosed through biopsy reports (Marsh 3, villous atrophy) from all 28 pathology departments in Sweden. Biopsies were performed in 1969-2008, and biopsy report data were collected in 2006-2008. Statistics Sweden then identified 85,166 reference individuals matched with the CD patients for age, sex, calendar period, and county.

Main Outcome Measure: PHPT was measured according to the Swedish national registers on inpatient care, outpatient care, day surgery, and cancer.

Results: During follow-up, 68 patients with CD and 172 reference individuals developed PHPT(HR = 1.91; 95% confidence interval = 1.44-2.52). The absolute risk of PHPT was 42/100,000 person-years with an excess risk of 20/100,000 person-years. The risk increase for PHPT only occurred in the first 5 yr of follow-up; after that, HR were close to 1 (HR = 1.07; 95% confidence interval = 0.70-1.66).

Conclusions: CD patients are at increased risk of PHPT, but the absolute risk is small, and the excess risk disappeared after more than 5 yr of follow-up. (J Clin Endocrinol Metab 97: 897-904, 2012)

Place, publisher, year, edition, pages
Endocrine Society , 2012. Vol. 97, no 3, p. 897-904
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:oru:diva-55821DOI: 10.1210/jc.2011-2639ISI: 000301229600055PubMedID: 22238405Scopus ID: 2-s2.0-84858062265OAI: oai:DiVA.org:oru-55821DiVA, id: diva2:1074963
Funder
Swedish Society of MedicineSwedish Research Council, 522-2A09-195
Note

Funding Agencies:

Sven Jerring Foundation

Örebro Society of Medicine

Karolinska Institutet

Örebro University Hospital

Clas Groschinsky Foundation

Juhlin Foundation

Majblomman Foundation

Uppsala-Örebro Regional Research Council

Swedish Celiac Society

American Scandinavian Foundation

Celiac Sprue Association

National Center for Research Resources, National Institutes of Health KL2 RR024157

Stockholm County Council (ALF)

National Institutes of Health DK084986

Research Ethics Committee of the Karolinska Institute, Sweden 2006/633-31/4

Available from: 2017-02-16 Created: 2017-02-16 Last updated: 2018-05-14Bibliographically approved

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