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Moderately increased risk of urinary stone disease in patients with biopsy-verified coeliac disease
Department of Paediatrics, Örebro University, Örebro University Hospital, Sweden; Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet Stockholm, Sweden.ORCID iD: 0000-0003-1024-5602
Department of Clinical and Experimental Medicine, Federico II University of Naples, Naples, Italy.
Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet Stockholm, Sweden.
Department of Gastroenterology, University of Salerno, Salerno, Italy.
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2012 (English)In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 35, no 4, 477-484 p.Article in journal (Refereed) Published
Abstract [en]

Background: Urinary stone disease is a mal-absorptive disorder that is a significant health problem because of its high prevalence and incidence. However, there are few population-based studies on the risk of urinary stone disease in patients with coeliac disease (CD).

Aim: To examine the risk of urinary stone disease in CD.

Methods: Population-based cohort study. Using small intestinal biopsy report data from 1969 to 2008 obtained from all Swedish pathology departments (n = 28), we identified 28 735 patients with CD (equal to Marsh 3: villous atrophy). Patients were then matched for gender, age, county and calendar year to 142 177 reference individuals from the Swedish general population. We used Cox regression to estimate hazard ratios (HRs) for future urinary stone disease and conditional logistic regression to calculate odds ratios (ORs) for urinary stone disease before diagnosis of CD. Individuals with urinary stone disease were identified through the Swedish National Patient Register that contains data on inpatient care, outpatient care and day surgery.

Results: During follow-up, 314 individuals with CD and 1142 reference individuals developed urinary stone disease. This corresponded to a 27% increased risk of urinary stone disease in CD [ 95% confidence interval (CI) = 1.12-1.44]. CD patients had an absolute risk of urinary stone disease of 107/ 100 000 personyears (excess risk of 23/ 100 000). Risk estimates were similar in men and women, and did not differ according to age at CD diagnosis. Conditional logistic regression found that patients with CD were at a slightly increased risk also of prior urinary stone disease (OR = 1.19; 95% CI = 1.06-1.33).

Conclusion: In this study, coeliac disease was associated with a moderately increased risk of urinary stone disease both before and after coeliac disease diagnosis.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2012. Vol. 35, no 4, 477-484 p.
National Category
Gastroenterology and Hepatology Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:oru:diva-55825DOI: 10.1111/j.1365-2036.2011.04968.xISI: 000299154900008PubMedID: 22221254Scopus ID: 2-s2.0-84856026725OAI: oai:DiVA.org:oru-55825DiVA: diva2:1075105
Available from: 2017-02-17 Created: 2017-02-17 Last updated: 2017-10-18Bibliographically approved

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