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Timing of Introduction of Gluten and Celiac Disease Risk
Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0003-1024-5602
Mucosal Biology Research Center, Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD, United States.
2012 (English)In: Annals of Nutrition and Metabolism, ISSN 0250-6807, E-ISSN 1421-9697, Vol. 60, no Suppl. 2, 22-29 p.Article in journal (Refereed) Published
Abstract [en]

Breast milk is the natural nutrition for infants, but in the second half of the first year of life, complementary feeding is needed. Many complementary foods contain gluten, but gluten exposure is associated with the risk of developing celiac disease (CD). CD is a disease with considerable morbidity and mortality. Although CD is associated with certain genetic features, carrying the human leukocyte antigen haplotypes DQ2 or DQ8 (a prerequisite for CD development) cannot fully explain who will or who will not develop CD. Potential risk factors for CD include perinatal events and infant feeding practice. With the exception that children who are breastfed at and beyond gluten introduction into the diet probably may be at a lower risk of developing CD, and that heavy gluten load early in life may increase the risk of future CD, data on the impact of infant feeding are inconsistent.

Place, publisher, year, edition, pages
S. Karger, 2012. Vol. 60, no Suppl. 2, 22-29 p.
Keyword [en]
Autoimmunity, Breastfeeding, Celiac disease, Gluten
National Category
Endocrinology and Diabetes Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:oru:diva-55861DOI: 10.1159/000335335ISI: 000303655000003PubMedID: 22555186Scopus ID: 2-s2.0-84860706471OAI: oai:DiVA.org:oru-55861DiVA: diva2:1075496
Funder
Swedish Research Council, 522-2A09-195Swedish Society of Medicine
Available from: 2017-02-20 Created: 2017-02-20 Last updated: 2017-10-18Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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