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Revisiting Recombination Signal in the Tick-Borne Encephalitis Virus: A Simulation Approach
Science and Historical Investigations of Evolution Laboratory of Dubá, Dubá, Czech Republic.
Örebro University, School of Medical Sciences. School of Natural Science, Technology and Environmental Studies, Södertörn University, Huddinge, Sweden; RiSC - Inflammatory Response and Infection Susceptibility Centre, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Department of Clinical Microbiology, Sahlgrenska University, Gothenburg, Sweden.
2016 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 10, e0164435Article in journal (Refereed) Published
Abstract [en]

The hypothesis of wide spread reticulate evolution in Tick-Borne Encephalitis virus (TBEV) has recently gained momentum with several publications describing past recombination events involving various TBEV clades. Despite a large body of work, no consensus has yet emerged on TBEV evolutionary dynamics. Understanding the occurrence and frequency of recombination in TBEV bears significant impact on epidemiology, evolution, and vaccination with live vaccines. In this study, we investigated the possibility of detecting recombination events in TBEV by simulating recombinations at several locations on the virus' phylogenetic tree and for different lengths of recombining fragments. We derived estimations of rates of true and false positive for the detection of past recombination events for seven recombination detection algorithms. Our analytical framework can be applied to any investigation dealing with the difficult task of distinguishing genuine recombination signal from background noise. Our results suggest that the problem of false positives associated with low detection P-values in TBEV, is more insidious than generally acknowledged. We reappraised the recombination signals present in the empirical data, and showed that reliable signals could only be obtained in a few cases when highly genetically divergent strains were involved, whereas false positives were common among genetically similar strains. We thus conclude that recombination among wild-type TBEV strains may occur, which has potential implications for vaccination with live vaccines, but that these events are surprisingly rare.

Place, publisher, year, edition, pages
Public Library of Science , 2016. Vol. 11, no 10, e0164435
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:oru:diva-56060DOI: 10.1371/journal.pone.0164435ISI: 000386204000036PubMedID: 27760182Scopus ID: 2-s2.0-84992395862OAI: oai:DiVA.org:oru-56060DiVA: diva2:1078582
Funder
Knowledge Foundation, 20150201
Note

Funding Agency:

Foundation for Baltic and East European Studies  1330/42/2010

Available from: 2017-03-06 Created: 2017-03-06 Last updated: 2017-04-06Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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