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Shared familial risk factors between attention-deficit/hyperactivity disorder and overweight/obesity: a population-based familial coaggregation study in Sweden
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
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2017 (English)In: Journal of Child Psychology and Psychiatry and Allied Disciplines, ISSN 0021-9630, E-ISSN 1469-7610, Vol. 58, no 6, 711-718 p.Article in journal (Refereed) Published
Abstract [en]

Background: Despite meta-analytic evidence for the association between attention-deficit/hyperactivity disorder (ADHD) and overweight/obesity, the mechanisms underlying the association are yet to be fully understood.

Methods By linking multiple Swedish national and regional registers, we identified 472,735 index males born during 1973-1992, with information on body weight and height directly measured before they were conscripted for military service. We further identified 523,237 full siblings born during 1973-2002 for the index males. All individuals were followed up from their third birthday to December 31, 2009 for ADHD diagnosis. Logistic regression models were used to estimate the association between overweight/obesity in index males and ADHD in their full siblings.

Results: Siblings of index males with overweight/obesity had increased risk for ADHD (overweight: OR = 1.14, 95% CI = 1.05-1.24; obesity: OR = 1.42, 95% CI = 1.24-1.63), compared with siblings of index males with normal weight. The results were adjusted for birth year of the index male and sex of the sibling. After further adjustment for ADHD status of the index male, the familial coaggregation remained significant (overweight: OR = 1.13, 95% CI = 1.04-1.22; obesity: OR = 1.38, 95% CI = 1.21-1.57). The results were similar across sex of the siblings.

Conclusions: Attention-deficit/hyperactivity disorder and overweight/obesity share familial risk factors, which are not limited to those causing overweight/obesity through the mediation of ADHD. Future research aiming at identifying family-wide environmental risk factors as well as common pleiotropic genetic variants contributing to both traits is warranted.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2017. Vol. 58, no 6, 711-718 p.
Keyword [en]
Attention-deficit; hyperactivity disorder; obesity; family factors; genetics
National Category
Psychiatry Psychology
Identifiers
URN: urn:nbn:se:oru:diva-55034DOI: 10.1111/jcpp.12686ISI: 000401731300009PubMedID: 28121008Scopus ID: 2-s2.0-85019629326OAI: oai:DiVA.org:oru-55034DiVA: diva2:1080413
Funder
Swedish Research Council, 2014-3831
Note

Funding Agencies:

Swedish Initiative for Research on Microdata in the Social and Medical Sciences (SIMSAM)  340-2013-5867 

European Union  667302  602805 

K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway  

NIMH  5R01MH101519 

Rhodes  

Arbor  

Pfizer  

Ironshore  

Shire  

Akili Interactive Labs  

CogCubed  

Alcobra  

VAYA Pharma  

NeuroLifeSciences  

NACE  

Solent National Health Service (NHS) Trust, UK

Available from: 2017-03-10 Created: 2017-03-10 Last updated: 2017-06-08Bibliographically approved

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CiteExportLink to record
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