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Physical and cognitive fitness in young adulthood and risk of amyotrophic lateral sclerosis at an early age
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Örebro University, School of Medical Sciences. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-6851-3297
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Lung and Allergy Unit, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
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2017 (English)In: European Journal of Neurology, ISSN 1351-5101, E-ISSN 1468-1331, Vol. 24, no 1, p. 137-142Article in journal (Refereed) Published
Abstract [en]

Background and purpose: There is a clinical impression that patients with amyotrophic lateral sclerosis (ALS) have a higher level of physical fitness and lower body mass index (BMI) than average. However, there is a lack of literature examining the relationship between cognitive fitness and ALS risk. In this study we explored the associations of both physical and cognitive fitness with future risk of ALS.

Methods: Data on physical fitness, BMI, intelligence quotient (IQ) and stress resilience were collected from 1 838 376 Swedish men aged 17-20 years at conscription during 1968-2010. Their subsequent ALS diagnoses were identified through the Swedish Patient Register. Hazard ratios (HRs) and 95% CIs from flexible parametric models were used to assess age-specific associations of physical fitness, BMI, IQ and stress resilience with ALS.

Results: We identified 439 incident ALS cases during follow-up (mean age at diagnosis: 48 years). Individuals with physical fitness above the highest tertile tended to have a higher risk of ALS before the age of 45 years (range of HRs: 1.42-1.75; statistically significant associations at age 41-43 years) compared with others. Individuals with BMI ≥ 25 tended to have a lower risk of ALS at all ages (range of HRs: 0.42-0.80; statistically significant associations at age 42-48 years) compared with those with BMI < 25. Individuals with IQ above the highest tertile had a statistically significantly increased risk of ALS at an age of 56 years and above (range of HRs: 1.33-1.81), whereas individuals with stress resilience above the highest tertile had a lower risk of ALS at an age of 55 years and below (range of HRs: 0.47-0.73).

Conclusions: Physical fitness, BMI, IQ and stress resilience in young adulthood might be associated with the development of ALS at an early age.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2017. Vol. 24, no 1, p. 137-142
Keywords [en]
Amyotrophic lateral sclerosis, body mass idex, cohort study, intelligence quotient, physical fitness, stress resilience
National Category
Neurology
Research subject
Neurology
Identifiers
URN: urn:nbn:se:oru:diva-54403DOI: 10.1111/ene.13165ISI: 000392806700010PubMedID: 28000353Scopus ID: 2-s2.0-84999633685OAI: oai:DiVA.org:oru-54403DiVA, id: diva2:1080471
Funder
Swedish Research Council, 2015-03170
Note

Funding Agencies:

Swedish Initiative for Research on Microdata in the Social and Medical Sciences 340-2013-5867

Swedish Society of Medical Research

Karolinska Institutet

EU

Available from: 2017-03-10 Created: 2017-03-10 Last updated: 2018-07-30Bibliographically approved

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