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Does p53 codon 72 polymorphism have a prognostic value in carcinoma of the vulva and vagina?
Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Örebro University Hospital. Örebro University, School of Health Sciences. Department of Oncology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.ORCID iD: 0000-0002-5063-631X
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Laboratory Medicine.ORCID iD: 0000-0003-2317-5738
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.ORCID iD: 0000-0001-6881-237X
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2017 (English)In: Medical Oncology, ISSN 1357-0560, E-ISSN 1559-131X, Vol. 34, no 3, 36Article in journal (Refereed) Published
Abstract [en]

Human papilloma virus (HPV) is considered to be responsible for a large part of vaginal and vulvar carcinomas, and the p53 codon 72 polymorphism has been implicated in susceptibility to cancer induced by this virus, but with contradicting results. In this study, we have investigated the prognostic value of the codon 72 polymorphism by real-time PCR (qPCR) in two cohorts of vaginal (n = 66) and vulvar (n = 123) carcinomas. In vaginal carcinoma, arginine homozygous patients were significantly associated with a higher primary cure rate (p = 0.023) but also associated with a higher recurrence rate (p = 0.073), significant at distant locations (p = 0.009). No significant differences were found in overall survival rate (p = 0.499) or cancer-specific survival rate (p = 0.222). A higher frequency of arginine homozygosity was noted in HPV-positive tumors (p = 0.190) in comparison with HPV-negative tumors. In vulvar carcinoma, the genotype homozygous for arginine was significantly associated with a larger tumor size at diagnosis in the entire cohort (p = 0.015) and a lower cancer-specific survival rate (p = 0.024) compared with heterozygous (arginine/proline) in HPV-negative tumors. Our results indicate that the relation between HPV and the p53 codon 72 polymorphism is complex and the significance and mechanisms responsible for this relationship need to be further elucidated.

Place, publisher, year, edition, pages
Heidelberg, Germany, 2017. Vol. 34, no 3, 36
Keyword [en]
P53, Codon 72, Polymorphism, Vagina, Vulva, Carcinoma, HPV
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-55410DOI: 10.1007/s12032-017-0893-6ISI: 000394277700006PubMedID: 28144815Scopus ID: 2-s2.0-85011707902OAI: oai:DiVA.org:oru-55410DiVA: diva2:1080516
Note

Funding Agencies:

Region Örebro County through ALF

Örebro County Council Research Committee

Available from: 2017-03-10 Created: 2017-03-10 Last updated: 2017-10-18Bibliographically approved

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Sorbe, BengtHelenius, GiselaKarlsson, Mats G.Lillsunde Larsson, Gabriella
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