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The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos
The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden; Institute for Clinical Molecular Biology, University of Kiel, Kiel, Germany.
The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.
Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute and Departments of Pharmacology and Cancer Biology and Medicine, Duke University Medical Center, Durham, USA.
Faculty of Forestry and Wildlife Management, Hedmark University College, Elverum, Norway; Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences, Umeå, Sweden.
Show others and affiliations
2016 (English)In: Cell reports, ISSN 2211-1247, E-ISSN 2211-1247, Vol. 14, no 7, 1655-1661 p.Article in journal (Refereed) Published
Abstract [en]

Hibernation is an adaptation that helps many animals to conserve energy during food shortage in winter. Brown bears double their fat depots during summer and use these stored lipids during hibernation. Although bears seasonally become obese, they remain metabolically healthy. We analyzed the microbiota of free-ranging brown bears during their active phase and hibernation. Compared to the active phase, hibernation microbiota had reduced diversity, reduced levels of Firmicutes and Actinobacteria, and increased levels of Bacteroidetes. Several metabolites involved in lipid metabolism, including triglycerides, cholesterol, and bile acids, were also affected by hibernation. Transplantation of the bear microbiota from summer and winter to germ-free mice transferred some of the seasonal metabolic features and demonstrated that the summer microbiota promoted adiposity without impairing glucose tolerance, suggesting that seasonal variation in the microbiota may contribute to host energy metabolism in the hibernating brown bear.

Place, publisher, year, edition, pages
Cambridge, USA: Cell Press , 2016. Vol. 14, no 7, 1655-1661 p.
Keyword [en]
Microbiota, obesity, metabolism, hibernation, brown bear
National Category
Nutrition and Dietetics Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:oru:diva-55982DOI: 10.1016/j.celrep.2016.01.026ISI: 000370970200010PubMedID: 26854221Scopus ID: 2-s2.0-84959156875OAI: oai:DiVA.org:oru-55982DiVA: diva2:1080682
Funder
Swedish Research CouncilTorsten Söderbergs stiftelseRagnar Söderbergs stiftelseNovo NordiskSwedish Foundation for Strategic Research Knut and Alice Wallenberg Foundation
Note

Funding Agencies:

IngaBritt and Arne Lundberg's foundation 

Region Västra Götaland 

Sahlgrenska University Hospital 

Lundbeck Foundation

Swedish Environmental Protection Agency 

Norwegian Environment Agency 

Swedish Association for Hunting and Wildlife Management 

WWF Sweden 

Research Council of Norway 

ERC Consolidator Grant (European Research Council) 

Scandinavian Brown Bear Research Project 

Available from: 2017-03-10 Created: 2017-03-10 Last updated: 2017-10-18Bibliographically approved

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