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A systematic review of sugammadex vs neostigmine for reversal of neuromuscular blockade
Dept Anaesthesia, Hosp Univ la Paz, Madrid, Spain.
Dept Anaesthesia, Hosp Univ Infanta Leonor, Univ Complutense Madrid, Madrid, Spain.
Dept Anaesthesia, Hosp Clin Univ Lozano Blesa, Zaragoza, Spain.
Dept Anaesthesia, Örebro University Hospital, Örebro, Sweden.
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2015 (English)In: Anaesthesia, ISSN 0003-2409, E-ISSN 1365-2044, Vol. 70, no 12, p. 1441-1452Article, review/survey (Refereed) Published
Abstract [en]

We reviewed systematically sugammadex vs neostigmine for reversing neuromuscular blockade. We included 17 randomised controlled trials with 1553 participants. Sugammadex reduced all signs of residual postoperative paralysis, relative risk (95% CI) 0.46 (0.29-0.71), p=0.0004 and minor respiratory events, relative risk (95% CI) 0.51 (0.32-0.80), p=0.0034. There was no difference in critical respiratory events, relative risk (95% CI) 0.13 (0.02-1.06), p=0.06. Sugammadex reduced drug-related side-effects, relative risk (95% CI) 0.72 (0.54-0.95), p=0.02. There was no difference in the rate of postoperative nausea or the rate of postoperative vomiting, relative risk (95% CI) 0.94 (0.79-1.13), p=0.53, and 0.87 (0.65-1.17), p=0.36 respectively.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2015. Vol. 70, no 12, p. 1441-1452
National Category
Anesthesiology and Intensive Care
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URN: urn:nbn:se:oru:diva-56286DOI: 10.1111/anae.13277ISI: 000364853600015PubMedID: 26558858OAI: oai:DiVA.org:oru-56286DiVA, id: diva2:1081122
Available from: 2017-03-13 Created: 2017-03-13 Last updated: 2018-07-06Bibliographically approved

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