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Circulating YKL-40 in patients with essential thrombocythemia and polycythemia vera treated with the novel histone deacetylase inhibitor vorinostat
Roskilde Univ Hosp, Dept Hematol, DK-4000 Roskilde, Denmark..
Roskilde Univ Hosp, Dept Hematol, DK-4000 Roskilde, Denmark..
Queen Univ Belfast, Dept Haematol, Belfast BT9 7AB, Antrim, North Ireland..
NHS Fdn Trust, Dept Haematol, London SE1 9R, England..
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2014 (English)In: Leukemia research: a Forum for Studies on Leukemia and Normal Hemopoiesis, ISSN 0145-2126, E-ISSN 1873-5835, Vol. 38, no 7, 816-821 p.Article in journal (Refereed) Published
Abstract [en]

YKL-40 regulates vascular endothelial growth factors and induces tumor proliferation. We investigated YKL-40 before and after treatment with vorinostat in 31 polycythemia vera (PV) and 16 essential thrombocythemia (ET) patients. Baseline PV patient levels were 2 times higher than in healthy controls (P<0.0001) and 1.7 times higher than in ET (P = 0.02). A significant correlation between YKL-40 at baseline and neutrophils, CRP, LDH, JAK2V617F and platelets in PV patients was observed, as well as a significantly greater reduction of YKL-40 levels in PV patients responding to therapy. YKL-40 might be a novel marker of disease burden and progression in myeloproliferative neoplasms.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 38, no 7, 816-821 p.
Keyword [en]
Yk1-40, Essential thrombocythemia, Polycythemia vera, Vorinostat, Phase II study
National Category
Cancer and Oncology Hematology
Identifiers
URN: urn:nbn:se:oru:diva-56308DOI: 10.1016/j.leukres.2014.04.002ISI: 000339339400015PubMedID: 24836761OAI: oai:DiVA.org:oru-56308DiVA: diva2:1081361
Available from: 2017-03-14 Created: 2017-03-14 Last updated: 2017-11-29Bibliographically approved

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Ahlstrand, ErikGronbaek, Kirsten
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Örebro University Hospital
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