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Gender-related differences in risk of cardiovascular morbidity and all-cause mortality in patients hospitalized with incident atrial fibrillation without concomitant diseases: A nationwide cohort study of 9519 patients
Orebro Univ Hosp, Dept Cardiol, S-70185 Orebro, Sweden..
Orebro Univ Hosp, Clin Epidemiol & Biostat Unit, S-70185 Orebro, Sweden..
Orebro Univ Hosp, Dept Occupat & Environm Med, S-70185 Orebro, Sweden..
Örebro University Hospital. Dept Cardiol.
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2014 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 177, no 1, 91-99 p.Article in journal (Refereed) Published
Abstract [en]

Background: Previous studies of patients with "lone" and "idiopathic" atrial fibrillation (AF) have provided conflicting evidence concerning the development, management and prognosis of this condition.

Methods: In this nation-wide, retrospective, cohort study, we studied patients diagnosed with incidental AF recorded in national Swedish registries between 1995 and 2008. Controls were matched for age, sex and calendar year of the diagnosis of AF in patients. All subjects were free of any in-hospital diagnosis from 1987 and until patients were diagnosed with AF and also free of any diagnosis within one year from the time of inclusion. Follow-up continued until 2009. We identified 9519 patients (31% women) and 12,468 matched controls.

Results: Relative risks (RR) versus controls for stroke or transient ischemic attack (TIA) in women were 19.6, 4.4, 3.4 and 2.5 in the age categories <55, 55-64, 65-74 and 75-85, years respectively. Corresponding figures for men were 3.4, 2.5, 1.7 and 1.9. RR for heart failure were 6.6, 6.6, 6.3 and 3.8 in women and 7.8, 4.6, 4.9 and 2.9 in men. All RR were statistically significant with p < 0.01. RR for myocardial infarction and all-cause mortality were statistically significantly increased only in the two oldest age categories in women and 65-74 years in men.

Conclusions: Patients with AF and no co-morbidities at inclusion had at least a doubled risk of stroke or TIA and a tripled risk of heart failure, through all age categories, as compared to controls. Women were at higher RR of stroke or TIA than men. (C) 2014 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/).

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 177, no 1, 91-99 p.
Keyword [en]
Atrial fibrillation, Cardiovascular morbidity, Mortality, Cohort, Nationwide
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:oru:diva-56310DOI: 10.1016/j.ijcard.2014.09.092ISI: 000343895000046PubMedID: 25499348OAI: oai:DiVA.org:oru-56310DiVA: diva2:1081365
Note

Funding Agencies:

AstraZeneca RD Mölndal

Örebro Heart Foundation

Research Committee of Örebro University Hospital OLL 2012-265231

Available from: 2017-03-14 Created: 2017-03-14 Last updated: 2017-11-29Bibliographically approved

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