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No increased mortality in 109,000 first-degree relatives of celiac individuals
Vardctr Varmlands Nysater, Primary Care Res Unit, S-66195 Varmlands Nysater, Varmland County, Sweden.;Univ Oslo, Inst Hlth & Soc, Dept Hlth Management & Hlth Econ, N-0316 Oslo, Norway..ORCID iD: 0000-0001-9137-2800
Univ Nottingham, City Hosp, Div Epidemiol & Publ Hlth, Clinical Sci Bldg,Hucknall Rd, Nottingham NG5 1PB, England.;Nottingham Univ Hosp NHS Trust, Biomed Res Unit, Nottingham Digest Dis Ctr, Natl Inst Hlth Res, Nottingham, England.;Univ Nottingham, Nottingham NG7 2RD, England..
Orebro University Hospital. Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.; Dept Pediat.
2016 (English)In: Digestive and Liver Disease, ISSN 1590-8658, E-ISSN 1878-3562, Vol. 48, no 4, 376-380 p.Article in journal (Refereed) Published
Abstract [en]

Background: Several studies have shown an excess mortality in individuals with celiac disease (CD). However, it is unknown if also first-degree relatives (FDRs) to celiac patients are at increased risk of death. Aim: We aimed to assess mortality in FDRs to celiac patients. Methods: Individuals with CD were identified through biopsy reports (equal to Marsh grade III). Each celiac individual was matched on sex, age, county and calendar year with up to five control individuals. Through Swedish healthcare registries we identified all FDRs (father, mother, sibling, offspring) of CD individuals and controls. Through Cox regression we calculated hazard ratios (HRs) for mortality (all-cause death, circulatory, cancer and other). Results: We identified 109,309 FDRs of celiac individuals and 549,098 FDRs of controls. Overall mortality was increased in FDRs to celiac individuals (HR = 1.02, 95%CI = 1.00-1.04, p = 0.03). This corresponded to an excess risk of 5.9 deaths per 100,000 person-years of follow-up. When limiting follow-up to time since celiac diagnosis in the index individual, we found no increased risk of death (HR = 1.01; 95%CI = 0.98-1.03). Conclusion: FDRs to individuals with CD are at increased risk of death. This excess risk is however minimal and unlikely to be of any clinical importance to the individual. (C) 2015 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 48, no 4, 376-380 p.
Keyword [en]
Coeliac, Death, Relatives, Shared genetics
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-56344DOI: 10.1016/j.dld.2015.11.016ISI: 000371993100005PubMedID: 26748422OAI: oai:DiVA.org:oru-56344DiVA: diva2:1081781
Available from: 2017-03-15 Created: 2017-03-15 Last updated: 2017-03-15Bibliographically approved

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Emilsson, LouiseLudvigsson, Jonas F.
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