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Population structure of Neisseria gonorrhoeae based on whole genome data and its relationship with antibiotic resistance
Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA 30322 USA..
Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA 30322 USA..
Univ Nacl Autonoma Mexico, Ctr Ciencias Genom, Programa Genom Evolut, Cuernavaca 62191, Morelos, Mexico..
Childrens Hosp, Oakland Res Inst, Oakland, CA 94609 USA.;Univ Calif San Francisco, Div Infect Dis, San Francisco, CA 94143 USA..
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2015 (English)In: PeerJ, ISSN 2167-8359, E-ISSN 2167-8359, Vol. 3, e806Article in journal (Refereed) Published
Abstract [en]

Neisseria gonorrhoeae is the causative agent of gonorrhea, a sexually transmitted infection (STI) of major importance. As a result of antibiotic resistance, there are now limited options for treating patients. We collected draft genome sequence data and associated metadata data on 76 N. gonorrhoeae strains from around the globe and searched for known determinants of antibiotics resistance within the strains. The population structure and evolutionary forces within the pathogen population were analyzed. Our results indicated a cosmopolitan gonoccocal population mainly made up of five subgroups. The estimated ratio of recombination to mutation (r/m = 2.2) from our data set indicates an appreciable level of recombination occurring in the population. Strains with resistance phenotypes to more recent antibiotics (azithromycin and cefixime) were mostly found in two of the five population subgroups.

Place, publisher, year, edition, pages
2015. Vol. 3, e806
Keyword [en]
Antimicrobial resistance, Population structure, Recombination, Whole genome sequence analysis, Genetic admixture
National Category
Microbiology
Identifiers
URN: urn:nbn:se:oru:diva-56350DOI: 10.7717/peerj.806ISI: 000350765400002PubMedID: 25780762OAI: oai:DiVA.org:oru-56350DiVA: diva2:1081814
Available from: 2017-03-15 Created: 2017-03-15 Last updated: 2017-03-15Bibliographically approved

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del Rio, CarlosDidelot, XavierUnemo, Magnus
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CiteExportLink to record
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Citation style
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