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Sick leave and disability pension in inflammatory bowel disease: A systematic review
Karolinska Inst, Dept Med Solna, Clin Epidemiol Unit, SE-17176 Stockholm, Sweden..
Univ Sao Paulo, Dept Prevent Med, Sao Paulo, Brazil..
Lorimer Enterprises Inc, Red Deer, AB, Canada..
Univ Sao Paulo, Dept Prevent Med, Sao Paulo, Brazil..
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2014 (English)In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 8, no 11, 1362-1377 p.Article, review/survey (Refereed) Published
Abstract [en]

Background & aims: Inflammatory bowel disease has considerable effects on work-related outcomes and leads to high societal costs due to sick leave and disability pension. The aims of this study were to systematically review evidence on work-related outcomes that are relevant to productivity losses and to evaluate whether medical or surgical interventions have a positive impact on patients work ability.

Methods: A systematic literature search in PubMed was conducted in June 2013. Abstracts were screened by two independent reviewers, and full-text articles describing the frequency of work-related outcomes were retrieved. Two independent reviewers extracted data according to the PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses. Findings were organized by study design (non-interventional/interventional). Non-interventional studies were structured according to whether they presented data in comparison to control groups or not and interventional studies were summarized according to type of intervention.

Results: This review included 30 non-interventional (15 with comparison groups and 15 without comparison group) and 17 interventional studies (9 surgical and 8 medical). The majority of the studies reported a high burden of work:related outcomes among inflammatory bowel disease patients regardless of the methodology used. While biologic agents showed positive effect on work absenteeism and presenteeism in randomized clinical trials, the impact of surgical interventions needs further evaluation.

Conclusions: Inflammatory bowel disease patients experience a high burden in work-related outcomes. Additional data on productivity losses and the long-term impact of interventions is needed to help inform decision-makers about treatment options and their benefits in reducing productivity losses in inflammatory bowel disease patients. (C) 2014 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 8, no 11, 1362-1377 p.
Keyword [en]
Work outcomes, Crohn's disease, Ulcerative colitis, Review
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-56357DOI: 10.1016/j.crohns.2014.06.006ISI: 000345182200003PubMedID: 25001582ScopusID: 2-s2.0-84920268292OAI: oai:DiVA.org:oru-56357DiVA: diva2:1081840
Note

Funding Agencies:

American Gastroenterological Association (AGA)

National Institute of Diabetes and Digestive and Kidney Diseases K23 DK099681

Karolinska Institutet Strategic Research Program in Epidemiology

Available from: 2017-03-15 Created: 2017-03-15 Last updated: 2017-03-15Bibliographically approved

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