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Six-week follow-up after HIV-1 exposure: a position statement from the Public Health Agency of Sweden and the Swedish Reference Group for Antiviral Therapy
Publ Hlth Agcy Sweden, S-17182 Solna, Sweden.;Karolinska Inst, Dept Med, Infect Dis Unit, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Infect Dis, Stockholm, Sweden..
Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Clin Microbiol, Stockholm, Sweden.;Swedish Reference Grp Antiviral Therapy, Stockholm, Sweden..
Publ Hlth Agcy Sweden, S-17182 Solna, Sweden..
Publ Hlth Agcy Sweden, S-17182 Solna, Sweden..
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2016 (English)In: INFECTIOUS DISEASES, ISSN 2374-4235, Vol. 48, no 2, 93-98 p.Article, review/survey (Refereed) Published
Abstract [en]

In 2014 the Public Health Agency of Sweden and the Swedish Reference Group for Antiviral Therapy (RAV) conducted a review and analysis of the state of knowledge on the duration of follow-up after exposure to human immunodeficiency virus (HIV). Up until then a follow-up of 12 weeks after exposure had been recommended, but improved tests and new information on early diagnosis motivated a re-evaluation of the national recommendations by experts representing infectious diseases and microbiology, county medical officers, the RAV, the Public Health Agency, and other national authorities. Based on the current state of knowledge the Public Health Agency of Sweden and the RAV recommend, starting in April 2015, a follow-up period of 6 weeks after possible HIV-1 exposure, if HIV testing is performed using laboratory-based combination tests detecting both HIV antibody and antigen. If point-of-care rapid HIV tests are used, a follow-up period of 8 weeks is recommended, because currently available rapid tests have insufficient sensitivity for detection of HIV-1 antigen. A follow-up period of 12 weeks is recommended after a possible exposure for HIV-2, since presently used assays do not include HIV-2 antigens and only limited information is available on the development of HIV antibodies during early HIV-2 infection. If pre- or post-exposure prophylaxis is administered, the follow-up period is recommended to begin after completion of prophylaxis. Even if infection cannot be reliably excluded before the end of the recommended follow-up period, HIV testing should be performed at first contact for persons who seek such testing.

Place, publisher, year, edition, pages
Taylor & Francis, 2016. Vol. 48, no 2, 93-98 p.
Keyword [en]
HIV follow-up window period, prophylaxis, HIV-1, HIV-2
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:oru:diva-56364DOI: 10.3109/23744235.2015.1089593ISI: 000371986500001PubMedID: 26414596OAI: oai:DiVA.org:oru-56364DiVA: diva2:1081885
Available from: 2017-03-15 Created: 2017-03-15 Last updated: 2017-03-15Bibliographically approved

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CiteExportLink to record
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