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Importance of Multidrug Efflux Pumps in the Antimicrobial Resistance Property of Clinical Multidrug-Resistant Isolates of Neisseria gonorrhoeae
National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden.
Department of Microbiology and Immunology, Emory University, School of Medicine, Atlanta, GA, United States; Laboratories of Bacterial Pathogenesis, Veterans Affairs Medical Center, Decatur, GA, United States.
National Institute of Infectious Diseases, Tokyo, Japan.
Orebro University Hospital. National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology.ORCID iD: 0000-0003-1710-2081
2014 (English)In: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, E-ISSN 1098-6596, Vol. 58, no 6, 3556-3559 p.Article in journal (Refereed) Published
Abstract [en]

The contribution of drug efflux pumps in clinical isolates of Neisseria gonorrhoeae that express extensively drug-resistant or multidrug-resistant phenotypes has heretofore not been examined. Accordingly, we assessed the effect on antimicrobial resistance of loss of the three gonococcal efflux pumps associated with a known capacity to export antimicrobials (MtrC-MtrD-MtrE, MacA-MacB, and NorM) in such clinical isolates. We report that the MIC of several antimicrobials, including seven previously and currently recommended for treatment was significantly impacted.

Place, publisher, year, edition, pages
American Society for Microbiology , 2014. Vol. 58, no 6, 3556-3559 p.
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:oru:diva-56403DOI: 10.1128/AAC.00038-14ISI: 000338776900075PubMedID: 24733458ScopusID: 2-s2.0-84901275120OAI: oai:DiVA.org:oru-56403DiVA: diva2:1082203
Note

Funding Agencies:

Research Committee of Örebro County

Örebro University Hospital Research Foundation, Örebro, Sweden

NIH R37 AI021150  U19 AI031496

VA Merit Award from the Medical Research Service of the Department of Veterans Affairs

Medical Research Service of the Department of Veterans Affairs

Available from: 2017-03-16 Created: 2017-03-16 Last updated: 2017-03-16Bibliographically approved

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CiteExportLink to record
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Citation style
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