Importance of Multidrug Efflux Pumps in the Antimicrobial Resistance Property of Clinical Multidrug-Resistant Isolates of Neisseria gonorrhoeae
2014 (English)In: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, E-ISSN 1098-6596, Vol. 58, no 6, 3556-3559 p.Article in journal (Refereed) Published
The contribution of drug efflux pumps in clinical isolates of Neisseria gonorrhoeae that express extensively drug-resistant or multidrug-resistant phenotypes has heretofore not been examined. Accordingly, we assessed the effect on antimicrobial resistance of loss of the three gonococcal efflux pumps associated with a known capacity to export antimicrobials (MtrC-MtrD-MtrE, MacA-MacB, and NorM) in such clinical isolates. We report that the MIC of several antimicrobials, including seven previously and currently recommended for treatment was significantly impacted.
Place, publisher, year, edition, pages
American Society for Microbiology , 2014. Vol. 58, no 6, 3556-3559 p.
Microbiology in the medical area
IdentifiersURN: urn:nbn:se:oru:diva-56403DOI: 10.1128/AAC.00038-14ISI: 000338776900075PubMedID: 24733458ScopusID: 2-s2.0-84901275120OAI: oai:DiVA.org:oru-56403DiVA: diva2:1082203
Research Committee of Örebro County
Örebro University Hospital Research Foundation, Örebro, Sweden
NIH R37 AI021150 U19 AI031496
VA Merit Award from the Medical Research Service of the Department of Veterans Affairs
Medical Research Service of the Department of Veterans Affairs2017-03-162017-03-162017-03-16Bibliographically approved