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Birth size in the most recent pregnancy and maternal mortality in premenopausal breast cancer by tumor characteristics
Dept Med, Clin Epidemiol Unit, Karolinska Inst, Stockholm, Sweden; Publ Hlth Fac, Dept Publ Hlth, Golestan Univ Med Sci, Gorgan, Iran.
Dept Med, Clin Epidemiol Unit, Karolinska Inst, Stockholm, Sweden.
Dept Med Epidemiol & Biostat, Karolinska Inst, Stockholm, Sweden.ORCID iD: 0000-0002-4624-3767
Sch Med, Dept Canc Biol, Univ Massachusetts, Worcester MA, USA.
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2014 (English)In: Breast Cancer Research and Treatment, ISSN 0167-6806, E-ISSN 1573-7217, Vol. 145, no 2, p. 471-480Article in journal (Refereed) Published
Abstract [en]

The main aim of this study was to investigate possible associations between measures of offspring size at birth in the most recent pregnancy before premenopausal breast cancer diagnosis and the risks of maternal breast cancer mortality, taking tumor characteristics into account. We also aimed to investigate if these associations are modified by age at childbirth, time since childbirth, parity, and age at diagnosis. We followed 6,019 women from their date of premenopausal breast cancer (diagnosed from 1992 to 2008) until emigration, death or December 31st, 2009, whichever occurred first. We used Cox proportional hazard regression models, adjusted for parity, age at diagnosis, and education level, to estimate associations between women pregnancy, cancer characteristics and offspring birth characteristics, and mothers' mortality risk. In stratified analyses, mortality risks were estimated by tumor stage, ER or PR status. There was no association between offspring birth weight (HR = 1.00, 95 % CI 0.99-1.01, when used as a continuous variable), birth weight for gestational age or ponderal index, and premenopausal breast cancer mortality. Similarly, in analyses stratified by tumor stage, receptor status, and time difference between last pregnancy and date of diagnosis, we found no associations between birth size and breast cancer mortality. Our findings suggest that the hypothesis that "premenopausal breast cancer mortality is associated with offspring birth characteristics in the most recent pregnancy before the diagnosis" may not be valid. In addition, these associations are not modified by tumor characteristics.

Place, publisher, year, edition, pages
Springer, 2014. Vol. 145, no 2, p. 471-480
Keywords [en]
Breast cancer, Premenopausal, Birth size, Estrogen receptor, Progesterone receptor
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-56424DOI: 10.1007/s10549-014-2956-0ISI: 000336370200020PubMedID: 24744092Scopus ID: 2-s2.0-84901695373OAI: oai:DiVA.org:oru-56424DiVA, id: diva2:1082292
Note

Funding Agencies:

Cancer Risk Prediction Center (CRisP)

Linneus Centre - Swedish Research Council 70867902

European Union 259679

Available from: 2017-03-16 Created: 2017-03-16 Last updated: 2018-06-20Bibliographically approved

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Lambe, MatsAhlgren, JohanAdolfsson, JanBahmanyar, Shahram
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Örebro University Hospital
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