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EuroSCORE II and N-terminal pro-B-type natriuretic peptide for risk evaluation: an observational longitudinal study in patients undergoing coronary artery bypass graft surgery
Linkoping Univ, Linkoping Univ Hosp, Dept Cardiothorac Surg & Anaesthesia, SE-58185 Linkoping, Sweden..
Orebro University Hospital. Department of Cardiothoracic Surgery and Anaesthesia.
Linkoping Univ, Linkoping Univ Hosp, Dept Cardiothorac Surg & Anaesthesia, SE-58185 Linkoping, Sweden..
Orebro University Hospital. Department of Cardiothoracic Surgery and Anaesthesia.
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2014 (English)In: British Journal of Anaesthesia, ISSN 0007-0912, E-ISSN 1471-6771, Vol. 113, no 1, 75-82 p.Article in journal (Refereed) Published
Abstract [en]

Background: Postoperative heart failure remains the major cause of death after cardiac surgery. As N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a predictor for postoperative heart failure, the aim was to evaluate if preoperative NT-proBNP could provide additional prognostic information to the recently launched EuroSCORE II.

Methods: A total of 365 patients with acute coronary syndrome (ACS) undergoing isolated coronary artery bypass graft (CABG) surgery were studied prospectively. Preoperative NT-proBNP and EuroSCORE II were evaluated with regard to severe circulatory failure after operation according to prespecified criteria. To assess what clinical outcomes are indicated by NT-proBNP levels in different risk categories, the patients were stratified according to EuroSCORE II. Based on receiver operating characteristics analysis, these cohorts were assessed with regard to preoperative NT-proBNP below or above 1028 ng litre(-1). The follow-up time averaged 4.4 (0.7) yr.

Results: Preoperative NT-proBNP >= 1028 ng litre(-1) [odds ratio (OR) 9.9,95% confidence interval (CI) 1.01-98.9; P=0.049] and EuroSCORE II (OR 1.24, 95% CI 1.06-1.46; P=0.008) independently predicted severe circulatory failure after operation. In intermediate-risk patients (EuroSCORE II 2.0-10.0), NT-proBNP >= 1028 ng litre(-1) was associated with a higher incidence of severe circulatory failure (6.6% vs 0%; P=0.007), renal failure (14.8% vs 5.4%; P=0.03), stroke (6.6% vs 0.7%; P=0.03), longer intensive care unit stay [37 (35) vs 27 (38) h; P=0.002], and worse long-term survival.

Conclusions: Combining EuroSCORE II and preoperative NT-proBNP appears to improve risk prediction with regard to severe circulatory failure after isolated CABG for ACS. NT-proBNP may be particularly useful in patients at intermediate risk according to EuroSCORE II.

Place, publisher, year, edition, pages
Oxford University Press, 2014. Vol. 113, no 1, 75-82 p.
Keyword [en]
acute coronary syndrome, coronary artery bypass surgery, natriuretic peptides, risk assessment
National Category
Anesthesiology and Intensive Care
Identifiers
URN: urn:nbn:se:oru:diva-56444DOI: 10.1093/bja/aeu088ISI: 000338598700011PubMedID: 24727704ScopusID: 2-s2.0-84903975900OAI: oai:DiVA.org:oru-56444DiVA: diva2:1082398
Funder
Swedish Heart Lung Foundation, 20030595
Note

Funding Agencies:

Capio Research Foundation 2005-1021  2006-1203

Linköping University

Östergotlands Läns Landsting 

Available from: 2017-03-16 Created: 2017-03-16 Last updated: 2017-03-16Bibliographically approved

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CiteExportLink to record
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