oru.sePublikationer
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Classification and Diagnostic Investigation in Inflammatory Myopathies: A Study of 99 Patients
Linkoping Univ, Dept Clin & Expt Med, Div Neurol, Fac Hlth Sci, Linkoping, Sweden. Linkoping Univ, Div Clin Immunol, Fac Hlth Sci, Linkoping, Sweden. Cty Council Ostergotland, Dept Neurol, Linkoping, Sweden. Cty Council Ostergotland, Dept Clin Immunol & Transfus Med, Linkoping, Sweden..
Orebro University Hospital. Dept Neurol.
Linkoping Univ, Dept Clin & Expt Med, Div Neurol, Fac Hlth Sci, Linkoping, Sweden. Linkoping Univ, Div Clin Immunol, Fac Hlth Sci, Linkoping, Sweden. Cty Council Ostergotland, Dept Neurol, Linkoping, Sweden. Cty Council Ostergotland, Dept Clin Immunol & Transfus Med, Linkoping, Sweden..
2013 (English)In: Journal of Rheumatology, ISSN 0315-162X, E-ISSN 1499-2752, Vol. 40, no 7, 1173-1182 p.Article in journal (Refereed) Published
Abstract [en]

Objective. Insights into the pathogenesis of inflammatory myopathies have led to new diagnostic methods. The aims of our study were (1) to evaluate the consequences of using the classification of Amato/European Neuromuscular Centre Workshop (ENMC), compared to that of Bohan and Peter; and (2) to evaluate any diagnostic benefit in using an extended pathological investigation. Methods. From a consecutive retrospective database, we evaluated 99 patients for classification. Patients with inclusion body myositis (IBM) were classified according to Griggs, et al. In addition to routine stainings and immunohistochemistry, a multilevel serial sectioning procedure was performed on paraffin-embedded material, to identify scarce pathological findings. Results. Classification according to Bohan and Peter could be performed for 83 of the 99 patients, whereas only 60 patients met the Amato/ENMC criteria, the latter resulting in the following diagnostic groups: IBM (n = 18), nonspecific myositis (n = 14), polymyositis (n = 12), dermatomyositis (n = 10), dermatomyositis sine dermatitis (n = 5), and immune-mediated necrotizing myopathy (n = 1). Most of the Amato/ENMC diagnostic groups harbored patients from several of the Bohan and Peter groups, which included a substantial group lacking proximal muscle weakness. The serial sectioning procedure was essential for classification of 9 patients (15%), and led to a more specific diagnosis for 13 patients (22%) according to Amato/ENMC. Conclusion. The classification of Amato/ENMC was more restrictive, forming groups based on clinical criteria and specified myopathological findings, which clearly differed from the groups of the Bohan and Peter classification. An extended pathological investigation increased the diagnostic yield of a muscle biopsy and highlights the quantity and specificity of certain pathological findings.

Place, publisher, year, edition, pages
2013. Vol. 40, no 7, 1173-1182 p.
Keyword [en]
INFLAMMATORY MYOPATHIES, IDIOPATHIC INFLAMMATORY MYOPATHIES, POLYMYOSITIS, DERMATOMYOSITIS, INCLUSION BODY MYOSITIS
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:oru:diva-56505DOI: 10.3899/jrheum.120804ISI: 000321993800023PubMedID: 23637317OAI: oai:DiVA.org:oru-56505DiVA: diva2:1082495
Available from: 2017-03-16 Created: 2017-03-16 Last updated: 2017-03-16Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Lindvall, Björn
By organisation
Orebro University Hospital
In the same journal
Journal of Rheumatology
Rheumatology and Autoimmunity

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf