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Low cardiac output as physiological phenomenon in hibernating, free-ranging Scandinavian brown bears (Ursus arctos) - an observational study
Univ Copenhagen, Gentofte Hosp, Dept Cardiol, Copenhagen, Denmark..
Hedmark Coll, Fac Appl Ecol & Agr Sci, Dept Forestry & Wildlife Management, NO-2418 Elverum, Norway.;Swedish Univ Agr Sci, Fac Forest Sci, Dept Wildlife Fish & Environm Studies, SE-90183 Umea, Sweden..
Norwegian Univ Life Sci, Dept Ecol & Nat Resource Management, NO-1528 As, Norway.;Norwegian Inst Nat Res, NO-7485 Trondheim, Norway..
Univ Copenhagen, Gentofte Hosp, Dept Cardiol, Copenhagen, Denmark..
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2014 (English)In: Cardiovascular Ultrasound, ISSN 1476-7120, E-ISSN 1476-7120, Vol. 12, 36Article in journal (Refereed) Published
Abstract [en]

Background: Despite 5-7 months of physical inactivity during hibernation, brown bears (Ursus arctos) are able to cope with physiological conditions that would be detrimental to humans. During hibernation, the tissue metabolic demands fall to 25% of the active state. Our objective was to assess cardiac function associated with metabolic depression in the hibernating vs. active states in free-ranging Scandinavian brown bears.

Methods: We performed echocardiography on seven free-ranging brown bears in Dalarna, Sweden, anesthetized with medetomidine-zolazepam-tiletamine-ketamine during winter hibernation in February 2013 and with medetomidine-zolazepam-tiletamine during active state in June 2013. We measured cardiac output noninvasively using estimates of hemodynamics obtained by pulsed wave Doppler echocardiography and 2D imaging. Comparisons were made using paired T-tests.

Results: During hibernation, all hemodynamic indices were significantly decreased (hibernating vs. active state): mean heart rate was 26.0 (standard deviation (SD): 5.6) beats per min vs. 75.0 (SD: 17.1) per min (P = 0.002), mean stroke volume 32.3 (SD: 5.2) ml vs. 47.1 (SD: 7.9) ml (P = 0.008), mean cardiac output 0.86 (SD: 0.31) l/min vs. 3.54 (SD: 1.04) l/min (P = 0.003), and mean cardiac index 0.63 (SD: 0.21) l/min/kg vs. 2.45 (SD: 0.52) l/min/ m(2) (P < 0.001). Spontaneous echo contrast was present in all cardiac chambers in all seven bears during hibernation, despite the absence of atrial arrhythmias and valvular disease.

Conclusion: Free-ranging brown bears demonstrate hemodynamics comparable to humans during active state, whereas during hibernation, we documented extremely low-flow hemodynamics. Understanding these physiological changes in bears may help to gain insight into the mechanisms of cardiogenic shock and heart failure in humans.

Place, publisher, year, edition, pages
BioMed Central, 2014. Vol. 12, 36
Keyword [en]
Animal model cardiovascular disease, Acute cardiac care, Thrombosis, Echocardiography
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:oru:diva-56513DOI: 10.1186/1476-7120-12-36ISI: 000342367900001PubMedID: 25224464ScopusID: 2-s2.0-84907586689OAI: oai:DiVA.org:oru-56513DiVA: diva2:1082574
Available from: 2017-03-17 Created: 2017-03-17 Last updated: 2017-03-17Bibliographically approved

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