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Swedish National Penile Cancer Register: incidence, tumour characteristics, management and survival
Örebro University Hospital. Department of Urology.
Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden..
Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden..
Uppsala Univ, Reg Canc Ctr Uppsala Orebro, Uppsala, Sweden.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
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2016 (English)In: BJU International, ISSN 1464-4096, E-ISSN 1464-410X, Vol. 117, no 2, p. 287-292Article in journal (Refereed) Published
Abstract [en]

Objectives: To assess penile cancer incidence, stage distribution, adherence to guidelines and prognostic factors in a population-based setting.

Patients and Methods: The population-based Swedish National Penile Cancer Register (NPECR) contains detailed information on tumour characteristics and management patterns. A total of 1 678 men with primary squamous cell carcinoma of the penis identified in the NPECR between 2000 and 2012 were included in the study.

Results: The mean age-adjusted incidence of penile cancer was 2.1/100 000 men, remaining virtually unchanged during the study period. At diagnosis, 14 and 2% of the men had clinical N+ and M+ disease, respectively. Most men were staged pTis (34%), pT2 (19%), or pT1 (18%), while stage information was unavailable for 18% of the men. Organ-preserving treatment was used in 71% of Tis-T1 tumours. Of men with cN0 and >= pT1G2 disease, 50% underwent lymph node staging, while 74% of men with cN1-3 disease underwent lymph node dissection. The overall 5-year relative survival rate was 82%. Men aged >= 40 years and those with pT2-3, G2-3 and N+ tumours had worse outcomes.

Conclusions: The incidence of penile cancer in Sweden is stable. Most men presented with localized disease, and the proportion of non-invasive tumours was high. During the period under study, adherence to guidelines was suboptimum. The overall 5-year relative survival rate was 82%. Older age, increasing tumour stage and grade, and increasing lymph node stage were associated with poorer survival.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2016. Vol. 117, no 2, p. 287-292
Keyword [en]
penile cancer, population-based, incidence, TNM, prognostic factors, survival
National Category
Urology and Nephrology
Identifiers
URN: urn:nbn:se:oru:diva-56516DOI: 10.1111/bju.12993ISI: 000367717300018PubMedID: 25395083Scopus ID: 2-s2.0-84954370794OAI: oai:DiVA.org:oru-56516DiVA, id: diva2:1082615
Available from: 2017-03-17 Created: 2017-03-17 Last updated: 2017-11-29Bibliographically approved

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